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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Synovial tumefactive extramedullary hematopoiesis associated to polycythemia vera.

The case of a 66-year-old male patient with a chronic myeloproliferative type polycythemia vera disorder, who after 2 years of evolution is developing a tumefactive extramedullary hematopoiesis (TEH) located in the synovial of the articulation in the right knee, is described. The tumor histologically consists of a relatively lax and edematous synovial structure diffusely infiltrated by mature and semimature hematopoietic cellular population. The simultaneous study of the bone marrow reveals medullar spaces full of hematopoietic cellularity, with a predominance of megakaryocytic and red series, and with the addition of severe reticulin fibrosis, facts that suggest a progression toward myelofibrosis. The TEH developed in tissues without a reticulum endothelial system is very uncommon. We provide data about the first case located in the synovial membrane and we review the literature regarding this pathologic entity.[1]

References

  1. Synovial tumefactive extramedullary hematopoiesis associated to polycythemia vera. Alvarez-Argüelles Cabrera, H., Carrasco Juan, J.L., García Castro, M.C., González Gaitano, M., Bonilla Arjona, A., Díaz-Flores, L. Virchows Arch. (2007) [Pubmed]
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