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Moubareck, C. et al.

Inhibitory Impact of Bifidobacteria on the Transfer of {beta}-Lactam Resistance among Enterobacteriaceae in the Gnotobiotic Mouse Digestive Tract.

While looking for new means to limit the dissemination of antibiotic resistance, we evaluated the role of potentially probiotic bifidobacteria on the transfer of resistance genes between enterobacteria. Transfers of bla genes encoding extended-spectrum beta-lactamases (SHV-5 and CTX-M-15) were studied in the absence or presence of bifidobacteria. In vitro, transfer frequencies of these bla genes decreased significantly in the presence of three of five tested strains, i.e., Bifidobacterium longum CUETM-89-215, Bifidobacterium bifidum CIP-56.7T, and Bifidobacterium pseudocatenulatum CIP-104168T. Four transfer experiments were conducted in the digestive tract of gnotobiotic mice, the first three observing the effect of B. longum CUETM-89-215, B. bifidum CIP-56.7T, and B. pseudocatenulatum CIP-104168T on bla(SHV-5) transfer and the fourth experiment studying the effect of B. bifidum CIP-56.7T on bla(CTX-M-15) transfer. These experiments revealed significant decreases in the transconjugant levels (up to 3 logs) in mice having received B. bifidum CIP-56.7T or B. pseudocatenulatum CIP-104168T compared to control mice. Bifidobacteria appear to have an inhibitory impact on the transfer of antibiotic resistance genes. The inhibitory effect is associated to specific bifidobacterial strains and may be related to the production of thermostable metabolites by these strains.[1]

References

Inhibitory Impact of Bifidobacteria on the Transfer of {beta}-Lactam Resistance among Enterobacteriaceae in the Gnotobiotic Mouse Digestive Tract. Moubareck, C., Lecso, M., Pinloche, E., Butel, M.J., Doucet-Populaire, F. Appl. Environ. Microbiol. (2007) [Pubmed]

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