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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Apoptosis of CD4+ T and Natural Killer Cells in Alzheimer's Disease.

BACKGROUND: Immunotherapy appears to be a potent treatment against Alzheimer's disease (AD), but the mechanisms underlying neural-immune interaction are still not known. METHODS: Here, we determined cell death and distribution of lymphocyte subsets of peripheral blood mononuclear cells (PBMC) in AD and aging, e.g. T (CD4 (+)CD3 (+), CD8 (+)CD3 (+)), B (CD19 (+)) and NK (CD16 (+)+CD56 (+)) cells. RESULTS: Increased apoptosis was found in CD4 (+) T and NK cells in AD, while in aging all subsets were affected. The expression of anti-apoptotic Bcl2 correlated with observed cell death in T-helper and B cells irrespective of dementia. The levels of Bcl2 in T-cells were significantly increased in mild AD. Apoptosis and Bcl2 levels were also elevated in the APP (751SL) x PS1 (M146L) transgenic mouse model. CONCLUSION: The mechanisms triggering apoptosis and activation of lymphocytes in AD appear therefore to be different than those in immunosenescence and possibly bear an important biomarker to monitor immunotherapy in AD.[1]

References

  1. Apoptosis of CD4+ T and Natural Killer Cells in Alzheimer's Disease. Schindowski, K., Peters, J., Gorriz, C., Schramm, U., Weinandi, T., Leutner, S., Maurer, K., Fr??lich, L., M??ller, W.E., Eckert, A. Pharmacopsychiatry (2006) [Pubmed]
 
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