Gene Review:
BCL2 - B-cell CLL/lymphoma 2
Homo sapiens
Synonyms:
Apoptosis regulator Bcl-2, Bcl-2, PPP1R50
von Deimling,
Fraga,
Krajewski,
Bellas,
Bemis,
Sáez,
Mollejo,
Flores,
Mazorra,
Dichgans,
Leutner,
Brady,
Gorriz,
Sánchez,
Reed,
Eckert,
Castaño,
Evan,
Alvaro,
M??ller,
Morente,
Fr??lich,
Miller,
Schramm,
Peters,
Maurer,
Harrold,
Berk,
Weinandi,
Martin,
Nelson,
De Tribolet,
Rieger,
Menárguez,
Díez,
Weller,
Robinson,
Schindowski,
Van Meir,
Montalbán,
Mestre,
Hueber,
Martinez,
Camacho,
García,
Grimmel,
Piris,
- Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. McGill, G.G., Horstmann, M., Widlund, H.R., Du, J., Motyckova, G., Nishimura, E.K., Lin, Y.L., Ramaswamy, S., Avery, W., Ding, H.F., Jordan, S.A., Jackson, I.J., Korsmeyer, S.J., Golub, T.R., Fisher, D.E. Cell (2002)
- Activation of MYC in a masked t(8;17) translocation results in an aggressive B-cell leukemia. Gauwerky, C.E., Huebner, K., Isobe, M., Nowell, P.C., Croce, C.M. Proc. Natl. Acad. Sci. U.S.A. (1989)
- Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas. Tanaka, S., Louie, D.C., Kant, J.A., Reed, J.C. Blood (1992)
- B-cell non-Hodgkin's lymphoma cell line (Karpas 1106) with complex translocation involving 18q21.3 but lacking BCL2 rearrangement and expression. Nacheva, E., Dyer, M.J., Metivier, C., Jadayel, D., Stranks, G., Morilla, R., Heward, J.M., Holloway, T., O'Connor, S., Bevan, P.C. Blood (1994)
- Bcl2 and human papilloma virus 16 as predictors of outcome following concurrent chemoradiation for advanced oropharyngeal cancer. Nichols, A.C., Finkelstein, D.M., Faquin, W.C., Westra, W.H., Mroz, E.A., Kneuertz, P., Begum, S., Michaud, W.A., Busse, P.M., Clark, J.R., Rocco, J.W. Clin. Cancer Res. (2010)
- Apoptosis of CD4+ T and Natural Killer Cells in Alzheimer's Disease. Schindowski, K., Peters, J., Gorriz, C., Schramm, U., Weinandi, T., Leutner, S., Maurer, K., Fr??lich, L., M??ller, W.E., Eckert, A. Pharmacopsychiatry (2006)
- BCL-2 family: regulators of cell death. Chao, D.T., Korsmeyer, S.J. Annu. Rev. Immunol. (1998)
- Decreased C-MYC and BCL2 expression correlates with methylprednisolone-mediated inhibition of Raji lymphoma growth. Morris, G., DeNardo, S.J., DeNardo, G.L., Leshchinsky, T., Wu, B., Mack, P.C., Winthrop, M.D., Gumerlock, P.H. Biochem. Mol. Med. (1997)
- Predicting chemoresistance in human malignant glioma cells: the role of molecular genetic analyses. Weller, M., Rieger, J., Grimmel, C., Van Meir, E.G., De Tribolet, N., Krajewski, S., Reed, J.C., von Deimling, A., Dichgans, J. Int. J. Cancer (1998)
- Gemcitabine cytotoxicity of human malignant glioma cells: modulation by antioxidants, BCL-2 and dexamethasone. Rieger, J., Durka, S., Streffer, J., Dichgans, J., Weller, M. Eur. J. Pharmacol. (1999)
- Down regulation of bcl2 expression in invasive ductal carcinomas is both estrogen- and progesterone-receptor dependent and associated with poor prognostic factors. Park, S.H., Kim, H., Song, B.J. Pathol. Oncol. Res. (2002)
- Enhancement of the efficacy of chemotherapy for lung cancer by simultaneous suppression of multidrug resistance and antiapoptotic cellular defense: novel multicomponent delivery system. Pakunlu, R.I., Wang, Y., Tsao, W., Pozharov, V., Cook, T.J., Minko, T. Cancer Res. (2004)
- mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Majumder, P.K., Febbo, P.G., Bikoff, R., Berger, R., Xue, Q., McMahon, L.M., Manola, J., Brugarolas, J., McDonnell, T.J., Golub, T.R., Loda, M., Lane, H.A., Sellers, W.R. Nat. Med. (2004)
- B-cell non-Hodgkin's lymphoma: evidence for the t (14;18) translocation in all hematopoietic cell lineages. Yarkoni, S., Lishner, M., Tangi, I., Nagler, A., Lorberboum-Galski, H. J. Natl. Cancer Inst. (1996)
- The Bcl-2 protein: a prognostic indicator strongly related to p53 protein in lymph node-negative breast cancer patients. Silvestrini, R., Veneroni, S., Daidone, M.G., Benini, E., Boracchi, P., Mezzetti, M., Di Fronzo, G., Rilke, F., Veronesi, U. J. Natl. Cancer Inst. (1994)
- Traps to catch unwary oncogenes. Hueber, A.O., Evan, G.I. Trends Genet. (1998)
- BCL2 translocation frequency rises with age in humans. Liu, Y., Hernandez, A.M., Shibata, D., Cortopassi, G.A. Proc. Natl. Acad. Sci. U.S.A. (1994)
- miR-15 and miR-16 induce apoptosis by targeting BCL2. Cimmino, A., Calin, G.A., Fabbri, M., Iorio, M.V., Ferracin, M., Shimizu, M., Wojcik, S.E., Aqeilan, R.I., Zupo, S., Dono, M., Rassenti, L., Alder, H., Volinia, S., Liu, C.G., Kipps, T.J., Negrini, M., Croce, C.M. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Myeloid cell leukemia 1 is phosphorylated through two distinct pathways, one associated with extracellular signal-regulated kinase activation and the other with G2/M accumulation or protein phosphatase 1/2A inhibition. Domina, A.M., Smith, J.H., Craig, R.W. J. Biol. Chem. (2000)
- BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma. Iqbal, J., Sanger, W.G., Horsman, D.E., Rosenwald, A., Pickering, D.L., Dave, B., Dave, S., Xiao, L., Cao, K., Zhu, Q., Sherman, S., Hans, C.P., Weisenburger, D.D., Greiner, T.C., Gascoyne, R.D., Ott, G., Müller-Hermelink, H.K., Delabie, J., Braziel, R.M., Jaffe, E.S., Campo, E., Lynch, J.C., Connors, J.M., Vose, J.M., Armitage, J.O., Grogan, T.M., Staudt, L.M., Chan, W.C. Am. J. Pathol. (2004)
- Expression of genes encoding innate host defense molecules in normal human monocytes in response to Candida albicans. Kim, H.S., Choi, E.H., Khan, J., Roilides, E., Francesconi, A., Kasai, M., Sein, T., Schaufele, R.L., Sakurai, K., Son, C.G., Greer, B.T., Chanock, S., Lyman, C.A., Walsh, T.J. Infect. Immun. (2005)
- BCL2 family in DNA damage and cell cycle control. Zinkel, S., Gross, A., Yang, E. Cell Death Differ. (2006)
- Combined effects of aberrant MEK1 activity and BCL2 overexpression on relieving the cytokine dependency of human and murine hematopoietic cells. Blalock, W.L., Moye, P.W., Chang, F., Pearce, M., Steelman, L.S., McMahon, M., McCubrey, J.A. Leukemia (2000)
- The microarray expression analysis identifies BAX as a mediator of beta-carotene effects on apoptosis. Bodzioch, M., Dembinska-Kiec, A., Hartwich, J., Lapicka-Bodzioch, K., Banas, A., Polus, A., Grzybowska, J., Wybranska, I., Dulinska, J., Gil, D., Laidler, P., Placha, W., Zawada, M., Balana-Nowak, A., Sacha, T., Kiec-Wilk, B., Skotnicki, A., Moehle, C., Langmann, T., Schmitz, G. Nutrition and cancer. (2005)
- The effect of flavopiridol on the growth of p16+ and p16- melanoma cell lines. Robinson, W.A., Miller, T.L., Harrold, E.A., Bemis, L.T., Brady, B.M., Nelson, R.P. Melanoma Res. (2003)
- Circumvention of multidrug resistance in genitourinary tumors. van Brussel, J.P., Mickisch, G.H. International journal of urology : official journal of the Japanese Urological Association. (1998)
- A protein kinase Cepsilon-anti-apoptotic kinase signaling complex protects human vascular endothelial cells against apoptosis through induction of Bcl-2. Steinberg, R., Harari, O.A., Lidington, E.A., Boyle, J.J., Nohadani, M., Samarel, A.M., Ohba, M., Haskard, D.O., Mason, J.C. J. Biol. Chem. (2007)
- BCL2 expression in chronic lymphocytic leukemia: lack of association with the BCL2 938A>C promoter single nucleotide polymorphism. Majid, A., Tsoulakis, O., Walewska, R., Gesk, S., Siebert, R., Kennedy, D.B., Dyer, M.J. Blood (2008)
- Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus. Berk, A.J. Oncogene (2005)
- HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Sowter, H.M., Ratcliffe, P.J., Watson, P., Greenberg, A.H., Harris, A.L. Cancer Res. (2001)
- Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2. Regl, G., Kasper, M., Schnidar, H., Eichberger, T., Neill, G.W., Philpott, M.P., Esterbauer, H., Hauser-Kronberger, C., Frischauf, A.M., Aberger, F. Cancer Res. (2004)
- The potential role of BAX and BCL-2 expression in diffuse alveolar damage. Guinee, D., Brambilla, E., Fleming, M., Hayashi, T., Rahn, M., Koss, M., Ferrans, V., Travis, W. Am. J. Pathol. (1997)
- BAG-1 expression in normal and neoplastic endometrium. Moriyama, T., Littell, R.D., Debernardo, R., Oliva, E., Lynch, M.P., Rueda, B.R., Duska, L.R. Gynecol. Oncol. (2004)
- BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. Yamamoto, K., Ichijo, H., Korsmeyer, S.J. Mol. Cell. Biol. (1999)
- Immunoglobulin heavy chain class switching, mu to gamma, in a human lymphoma cell line FL-318 carrying a t(14;18)(q32;q21) chromosomal translocation. Kadowaki, N., Amakawa, R., Hayashi, T., Akasaka, T., Yabumoto, K., Ohno, H., Fukuhara, S., Okuma, M. Leukemia (1995)
- Inhibitory effect of Bcl-2 on p53-mediated transactivation following genotoxic stress. Zhan, Q., Kontny, U., Iglesias, M., Alamo, I., Yu, K., Hollander, M.C., Woodworth, C.D., Fornace, A.J. Oncogene (1999)
- Overexpression of BCL2 blocks TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human lung cancer cells. Sun, S.Y., Yue, P., Zhou, J.Y., Wang, Y., Choi Kim, H.R., Lotan, R., Wu, G.S. Biochem. Biophys. Res. Commun. (2001)
- Both Stat3-activation and Stat3-independent BCL2 downregulation are important for interleukin-6-induced apoptosis of 1A9-M cells. Oritani, K., Tomiyama, Y., Kincade, P.W., Aoyama, K., Yokota, T., Matsumura, I., Kanakura, Y., Nakajima, K., Hirano, T., Matsuzawa, Y. Blood (1999)
- Regulation of MCL1 through a serum response factor/Elk-1-mediated mechanism links expression of a viability-promoting member of the BCL2 family to the induction of hematopoietic cell differentiation. Townsend, K.J., Zhou, P., Qian, L., Bieszczad, C.K., Lowrey, C.H., Yen, A., Craig, R.W. J. Biol. Chem. (1999)
- Catalase plays a critical role in the CSF-independent survival of human macrophages via regulation of the expression of BCL-2 family. Komuro, I., Yasuda, T., Iwamoto, A., Akagawa, K.S. J. Biol. Chem. (2005)
- Hodgkin and Reed-Sternberg cells harbor alterations in the major tumor suppressor pathways and cell-cycle checkpoints: analyses using tissue microarrays. García, J.F., Camacho, F.I., Morente, M., Fraga, M., Montalbán, C., Alvaro, T., Bellas, C., Castaño, A., Díez, A., Flores, T., Martin, C., Martinez, M.A., Mazorra, F., Menárguez, J., Mestre, M.J., Mollejo, M., Sáez, A.I., Sánchez, L., Piris, M.A. Blood (2003)
- Increased number of chromosomal imbalances and high-level DNA amplifications in mantle cell lymphoma are associated with blastoid variants. Beà, S., Ribas, M., Hernández, J.M., Bosch, F., Pinyol, M., Hernández, L., García, J.L., Flores, T., González, M., López-Guillermo, A., Piris, M.A., Cardesa, A., Montserrat, E., Miró, R., Campo, E. Blood (1999)
- Vascular endothelial growth factor inhibits apoptotic death in hematopoietic cells after exposure to chemotherapeutic drugs by inducing MCL1 acting as an antiapoptotic factor. Katoh, O., Takahashi, T., Oguri, T., Kuramoto, K., Mihara, K., Kobayashi, M., Hirata, S., Watanabe, H. Cancer Res. (1998)
- Bcl2 inhibits abasic site repair by down-regulating APE1 endonuclease activity. Zhao, J., Gao, F., Zhang, Y., Wei, K., Liu, Y., Deng, X. J. Biol. Chem. (2008)
- Clinical relevance of BCL2, BCL6, and MYC rearrangements in diffuse large B-cell lymphoma. Kramer, M.H., Hermans, J., Wijburg, E., Philippo, K., Geelen, E., van Krieken, J.H., de Jong, D., Maartense, E., Schuuring, E., Kluin, P.M. Blood (1998)
- Concurrent activation of MYC and BCL2 in B cell non-Hodgkin lymphoma cell lines by translocation of both oncogenes to the same immunoglobulin heavy chain locus. Dyer, M.J., Lillington, D.M., Bastard, C., Tilly, H., Lens, D., Heward, J.M., Stranks, G., Morilla, R., Monrad, S., Guglielmi, P., Kluin-Nelemans, J.C., Hagemeijer, A., Young, B.D., Catovsky, D. Leukemia (1996)
- Characterization of a novel malignant B cell line with t(14;18) and t(4;11) established from a patient with acute monoblastic leukemia. de Kroon, J.F., Kluin-Nelemans, H.C., Kluin, P.M., Schuuring, E., van Bergen, C.A., Oving, I., Wessels, H., Willemze, R., Falkenburg, J.H. Exp. Hematol. (1997)