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Mousa, S.A. et al.

Mousa, Davis, Mohamed, Davis, Feng,

Pro-angiogenesis action of thyroid hormone and analogs in a three-dimensional in vitro microvascular endothelial sprouting model.

AIM: Our laboratory has recently demonstrated the pro-angiogenesis effects of thyroid hormone in the chick chorioallantoic membrane model. METHODS: Generation of new blood vessels from existing vessels was promoted two- to three-fold by either L-thyroxine (T(4)) or 3,5,3'-triiodo-L-thyronine (T(3)) at total hormone concentrations of T(7)-T(9) M. RESULTS: T(4)-agarose, a formulation of thyroid hormone that does not cross the cell membrane, produced a potent pro-angiogenesis effect comparable to that obtained with T(3) or T(4). In the present investigation, T(3), T(4), T(4)-agarose, and basic fibroblast growth factor, each added to vascular endothelial growth factor, produced comparable pro-angiogenesis effects in the in vitro three-dimensional human microvascular endothelial sprouting model. The pro-angiogenesis effect of the thyroid hormone analogs was blocked by PD 98059, an inhibitor of the mitogen-activated protein kinase ( MAPK; ERK1/2) signal transduction cascade. A specific avb3 integrin antagonist (XT199) also inhibited the pro-angiogenesis effect of either thyroid hormone analogs or T(4)-agarose. Tetrac, a thyroid hormone analog that blocks cell surface-initiated actions of T(4) and T(3), inhibited the pro-angiogenesis response of thyroid hormone. CONCLUSIONS: T(4), T(3), and T(4)-agarose are pro-angiogenic in the three-dimensional human microvascular endothelial sprouting model, an action that is initiated at the plasma membrane, involves avb3 integrin receptors, and is MAPK-dependent.[1]

References

Pro-angiogenesis action of thyroid hormone and analogs in a three-dimensional in vitro microvascular endothelial sprouting model. Mousa, S.A., Davis, F.B., Mohamed, S., Davis, P.J., Feng, X. International angiology : a journal of the International Union of Angiology (2006) [Pubmed]

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