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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Functional expression of chemokine receptor CCR6 on human effector memory CD8(+) T cells.

Since CCR6 is a receptor for the chemokine CCL20, which is produced in tissues such as intestine and colon, it is thought that T cells expressing CCR6 are involved in mucosal immunity. The expression and function of CCR6 on human CD8(+) T cells have not well been analyzed, although it is known that this receptor is expressed on a subset of human CD8(+) T cells. We here characterize human CCR6(+) CD8(+) T cells. Multi-color flow cytometric analysis demonstrated that CCR6(+) cells are predominantly found among CD8(+) T cells having the memory phenotype. The expression of CCR6 is positively and negatively correlated with that of CCR5 and CCR7, respectively. CCR6(+) CD8(+) T cells express granzyme A and a low level of perforin but not granzyme B. In addition, a major population among these cells has the ability to produce IFN-gamma and TNF-alpha but not IL-2. These results indicate that CCR6(+) CD8(+) T cells have characteristics of early effector memory cells rather than effector or central memory cells. A chemotaxis assay revealed that CCR6(+) CD8(+) T cells have the ability to migrate in response to CCL20, suggesting that these T cells migrate to tissues such as colon and are involved in mucosal immunity.[1]


  1. Functional expression of chemokine receptor CCR6 on human effector memory CD8(+) T cells. Kondo, T., Takata, H., Takiguchi, M. Eur. J. Immunol. (2007) [Pubmed]
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