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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The pharmacology of an insect ganglion: actions of carbamylcholine and acetylcholine.

1. Methods for presenting dose-response data for the ganglionic actions of cholinergic agonists (e.g. carbamylcholine) are compared, using the mannitol-gap technique for electrophysiological recording of synaptic events at the cercal nerve, giant fibre synapse of the sixth abdominal ganglion of the cockroach Periplaneta americana. 2. At concentrations around 10(-5)M, carbamylcholine has no effect on ganglionic polarization but potentiates the monosynaptic EPSP. At 10(-4)M and higher concentrations, ganglionic depolarization is accompanied by a reduction of EPSP. 3. Pretreatment with eserine (10(-6) M) considerably shifts the dose-response curve for acetylcholine so that synaptic transmission is consistently sensitive to 10(-6) M acetylcholine.[1]

References

  1. The pharmacology of an insect ganglion: actions of carbamylcholine and acetylcholine. Sattelle, D.B., McClay, A.S., Dowson, R.J., Callec, J.J. J. Exp. Biol. (1976) [Pubmed]
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