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Dimitriadis, G. et al.

George Dimitriadis, Vaia Lambadiari, Panayota Mitrou, Eirini Maratou, Eleni Boutati, Demosthenes B. Panagiotakos, Theofanis Economopoulos, Sotirios A. Raptis,

Impaired postprandial blood flow in adipose tissue may be an early marker of insulin resistance in type 2 diabetes.

OBJECTIVE: We investigated the changes in subcutaneous adipose tissue blood flow (ATBF) after a meal in the various stages of type 2 diabetes. RESEARCH DESIGN AND METHODS: Five groups were examined: healthy control subjects, first-degree relatives of subjects with type 2 diabetes, subjects with impaired glucose tolerance (IGT), subjects with type 2 diabetes and postprandial hyperglycemia but normal fasting plasma glucose levels (diabetes group A [DMA]), and subjects with type 2 diabetes with both postprandial and fasting hyperglycemia (diabetes group B [DMB]). ATBF was measured with (133)Xe. RESULTS: ATBF was higher in control subjects (1,507 +/- 103 ml/100 cm(3) tissue x min) versus relatives and IGT, DMA, and DMB subjects (845 +/- 123, 679 +/- 69, 765 +/- 60, and 757 +/- 69 ml/100 cm(3) tissue x min, respectively; P < 0.001). Insulin sensitivity index (ISI) in control subjects (82 +/- 3 mg x l(2)/mmol x mU x min) was higher versus that for relatives and IGT, DMA, and DMB subjects (60 +/- 3, 45 +/- 1, 40 +/- 6, and 29 +/- 4 mg x l(2)/mmol x mU x min, respectively; P < 0.0001). ISI was positively associated with peak-baseline ATBF (beta coefficient 0.029 +/- 0.013, P = 0.03). CONCLUSIONS: After meal ingestion, insulin-stimulated ATBF was decreased in relatives and and IGT, DMA, and DMB subjects. This defect could be an early marker of insulin resistance that precedes the development of type 2 diabetes.[1]

References

Impaired postprandial blood flow in adipose tissue may be an early marker of insulin resistance in type 2 diabetes. Dimitriadis, G., Lambadiari, V., Mitrou, P., Maratou, E., Boutati, E., Panagiotakos, D.B., Economopoulos, T., Raptis, S.A. Diabetes. Care (2007) [Pubmed]

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