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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Macrophage activation in vivax malaria: fever is associated with increased levels of neopterin and interferon-gamma.

In order to evaluate the relationship between fever and macrophage activation in vivax malaria, serum interferon-gamma (IFN-gamma) and urinary neopterin concentrations were determined in Thai adults with Plasmodium vivax parasitaemia. Magnitude of fever, after controlling for parasite density, was found to be positively correlated with both IFN-gamma (r = 0.47) and neopterin (r = 0.57). In the 26 febrile patients, neopterin excretion increased further during the first two days of chemotherapy (P = 0.0002). Mean neopterin values for both groups had fallen to within the normal range by the sixth day post-treatment. Thus, the fever of vivax malaria was associated with IFN-gamma induced macrophage activation, as reflected by neopterin excretion.[1]

References

  1. Macrophage activation in vivax malaria: fever is associated with increased levels of neopterin and interferon-gamma. Brown, A.E., Teja-Isavadharm, P., Webster, H.K. Parasite Immunol. (1991) [Pubmed]
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