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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Weinshenker, B.G. et al.

B.G. Weinshenker, D.M. Wingerchuk,

Neuromyelitis optica: clinical syndrome and the NMO-IgG autoantibody marker.

Neuromyelitis optica (NMO) is a severe demyelinating disease of the CNS that preferentially affects the optic nerves and spinal cord, tends to relapse, and results in early permanent disability for most affected patients. A new autoantibody marker called neuromyelitis optica immunoglobulin G (NMO-IgG), which targets the water channel protein aquaporin-4, is highly specific for NMO. The marker has demonstrated that the NMO spectrum of disorders is wider than previously known and includes some patients with single-episode or recurrent longitudinally extensive myelitis, recurrent isolated optic neuritis, Asian optic-spinal multiple sclerosis, and patients with co-existing systemic autoimmune diseases such as lupus erythematosus or Sjögren's syndrome. We review the place of NMO within the nosology of CNS demyelinating diseases, the discovery of NMO-IgG and its impact on the definition of NMO and its spectrum, implications for understanding NMO pathogenesis, and informing treatment decisions.[1]

References

Neuromyelitis optica: clinical syndrome and the NMO-IgG autoantibody marker. Weinshenker, B.G., Wingerchuk, D.M. Curr. Top. Microbiol. Immunol. (2008) [Pubmed]

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