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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Myelitis


High impact information on Myelitis

  • Average cord MTR was lower in patients with cervical (P < 0.0001) and dorsal (P = 0.0001) myelitis than in controls [6].
  • Myelitis in systemic lupus erythematosus [7].
  • Persistent multiple pulmonary nodules in a nonimmunocompromised woman after varicella-related myelitis treated with acyclovir [8].
  • In contrast, in hyperIgEaemic myelitis, in addition to a significantly lower intracellular IFN-gamma/IL-4 ratio in CD4+ T cells, a tendency toward a lower intracellular IFN-gamma/IL-4 ratio in CD8+ T cells in comparison to the healthy controls was observed [9].
  • Therefore, acute localised myelitis with hyperIgEaemia, in which atopy to mite antigens seems to exist, may be a distinct subtype of allergic myelitis-that is, atopic myelitis [10].

Chemical compound and disease context of Myelitis


Biological context of Myelitis

  • Isolated myelitis of lumbosacral segments of the spinal cord, apparently confined to the grey matter, was diagnosed and its spirochaetal aetiology confirmed by serology and CSF findings [16].

Anatomical context of Myelitis


Gene context of Myelitis

  • GFAP-specific oligoclonal bands in the CSF of a patient with acute myelitis [22].
  • We describe a fatal case of varicella-zoster virus myelitis that was preceded by neurological symptoms for 10 months in a patient with human immunodeficiency virus infection and an extremely low CD4 cell count (20/microL) [23].
  • Therefore, it was not possible to investigate the influence of potentially contributing factors on the occurrence of radiation myelitis, such as interfraction interval, cord length, and administration of concurrent CDDP [24].
  • CONCLUSIONS: Given the increasing number of studies with both altered fractionated regimens and concurrent radio-chemotherapy in SCC H&N, new studies with more patients are needed to gain better insight into the risks of developing cervical radiation myelitis [24].
  • In the absence of detectable amount of HTLV-I antigens at the sites of inflammation, "chronic progressive parainfectious myelitis" seems to be the most appropriate descriptive term for this unique histopathology of HAM/TSP [25].

Analytical, diagnostic and therapeutic context of Myelitis

  • We conclude that (1) VZV should be considered a curable cause of myelitis in patients with AIDS, (2) PCR assay of CSF will assist in early diagnosis, and (3) early treatment with acyclovir should aid in recovery [26].
  • The intrathecal gadolinium-enhanced MR myelography revealed disk herniation (n = 4), posttraumatic spinal stenosis (n = 3), postsurgical noncommunicating cyst (n = 1), myelitis (n = 1), intradural extramedullary mass formation (n = 1), and intradural vascular malformation (n = 1) [27].


  1. Risk factors associated with equine motor neuron disease: a possible model for human MND. Mohammed, H.O., Cummings, J.F., Divers, T.J., Valentine, B., de Lahunta, A., Summers, B., Farrow, B.R., Trembicki-Graves, K., Mauskopf, A. Neurology (1993) [Pubmed]
  2. Multiple sclerosis or HTLV-I myelitis? Poser, C.M., Roman, G.C., Vernant, J.C. Neurology (1990) [Pubmed]
  3. Myelitis. Andersen, O. Curr. Opin. Neurol. (2000) [Pubmed]
  4. Herpes zoster myelitis treated with vidarabine. Cullis, P.A., Gilroy, J., Cushing, R. J. Neurol. Neurosurg. Psychiatr. (1982) [Pubmed]
  5. A pathogenic role of Th2 responses on the severity of encephalomyelitis induced in mice by herpes simplex virus type 2 infection. Nakajima, H., Kobayashi, M., Pollard, R.B., Suzuki, F. J. Neuroimmunol. (2000) [Pubmed]
  6. The level of spinal cord involvement influences the pattern of movement-associated cortical recruitment in patients with isolated myelitis. Rocca, M.A., Agosta, F., Martinelli, V., Falini, A., Comi, G., Filippi, M. Neuroimage (2006) [Pubmed]
  7. Myelitis in systemic lupus erythematosus. de Brum-Fernandes, A.J., Lucena-Fernandes, M.F., Levy Neto, M., Cossermelli, W. Arthritis Rheum. (1987) [Pubmed]
  8. Persistent multiple pulmonary nodules in a nonimmunocompromised woman after varicella-related myelitis treated with acyclovir. Schvoerer, E., Frechin, V., Warter, A., Gasser, B., Jouin, H., Gut, J.P., Stoll-Keller, F. J. Clin. Microbiol. (2003) [Pubmed]
  9. Tc1/Tc2 and Th1/Th2 balance in Asian and Western types of multiple sclerosis, HTLV-I-associated myelopathy/tropical spastic paraparesis and hyperIgEaemic myelitis. Ochi, H., Wu, X.M., Osoegawa, M., Horiuchi, I., Minohara, M., Murai, H., Ohyagi, Y., Furuya, H., Kira, J. J. Neuroimmunol. (2001) [Pubmed]
  10. Acute myelitis with hyperIgEaemia and mite antigen specific IgE: atopic myelitis. Kira, J., Kawano, Y., Yamasaki, K., Tobimatsu, S. J. Neurol. Neurosurg. Psychiatr. (1998) [Pubmed]
  11. Acute transverse myelopathy: spinal and cranial MR study with clinical follow-up. Campi, A., Filippi, M., Comi, G., Martinelli, V., Baratti, C., Rovaris, M., Scotti, G. AJNR. American journal of neuroradiology. (1995) [Pubmed]
  12. Neuromyelitis optica after a spinal anaesthesia with bupivacaine. Hosseini, H., Brugieres, P., Degos, J.D., Cesaro, P. Mult. Scler. (2003) [Pubmed]
  13. Vascular steal mimicking compression myelopathy in Paget's disease of bone: rapid reversal with calcitonin and systemic steroids. Yost, J.H., Spencer-Green, G., Krant, J.D. J. Rheumatol. (1993) [Pubmed]
  14. Systemic lupus erythematosus associated with transverse myelitis and parkinsonian symptoms. Osawa, H., Yamabe, H., Kaizuka, M., Tamura, N., Tsunoda, S., Shirato, K.I., Okumura, K. Lupus (1997) [Pubmed]
  15. Radiation myelitis following craniospinal irradiation with concurrent actinomycin-D therapy. Littman, P., Rosenstock, J.G., Bailey, C. Med. Pediatr. Oncol. (1978) [Pubmed]
  16. Borrelia burgdorferi myelitis presenting as a partial stiff man syndrome. Martin, R., Meinck, H.M., Schulte-Mattler, W., Ricker, K., Mertens, H.G. J. Neurol. (1990) [Pubmed]
  17. First episode of acute CNS inflammatory demyelination in childhood: prognostic factors for multiple sclerosis and disability. Mikaeloff, Y., Suissa, S., Vallée, L., Lubetzki, C., Ponsot, G., Confavreux, C., Tardieu, M. J. Pediatr. (2004) [Pubmed]
  18. Cervical myelitis from herpes simplex virus type 1. Mewasingh, L.D., Christiaens, F.J., Dachy, B., Christophe, C., Dan, B. Pediatric neurology. (2004) [Pubmed]
  19. Density distribution and size of megakaryocytes in inflammatory reactions of the bone marrow (myelitis) and chronic myeloproliferative diseases. Thiele, J., Holgado, S., Choritz, H., Georgii, A. Scandinavian journal of haematology. (1983) [Pubmed]
  20. A case of neuropsychiatric lupus with myelopathy successfully treated with corticosteroids. Salmi, H.H., Shalaby, M.A., Ageely, H.M., Moustafa, F. West African journal of medicine. (2004) [Pubmed]
  21. Ki-S1 and proliferating cell nuclear antigen expression of bone marrow macrophages. Immunohistochemical and morphometric study including reactive (inflammatory) myelitis, secondary aplastic anemia, AIDS, myelodysplastic syndromes and primary (idiopathic) osteomyelofibrosis. Titius, B.R., Thiele, J., Schaefer, H., Kreipe, H., Fischer, R. Acta Haematol. (1994) [Pubmed]
  22. GFAP-specific oligoclonal bands in the CSF of a patient with acute myelitis. Kaiser, R., Lücking, C.H. Acta neurologica Scandinavica. (1993) [Pubmed]
  23. Chronic varicella-zoster virus myelitis without cutaneous eruption in a patient with AIDS: report of a fatal case. Manian, F.A., Kindred, M., Fulling, K.H. Clin. Infect. Dis. (1995) [Pubmed]
  24. Absence of cervical radiation myelitis after hyperfractionated radiation therapy with and without concurrent chemotherapy for locally advanced, unresectable, nonmetastatic squamous cell carcinoma of the head and neck. Jeremic, B., Shibamoto, Y., Igrutinovic, I. J. Cancer Res. Clin. Oncol. (2001) [Pubmed]
  25. Pathology of chronic myelopathy associated with HTLV-I infection (HAM/TSP). Iwasaki, Y. J. Neurol. Sci. (1990) [Pubmed]
  26. Myelitis due to varicella-zoster virus in two patients with AIDS: successful treatment with acyclovir. Lionnet, F., Pulik, M., Genet, P., Petitdidier, C., Davous, P., Lebon, P., Rozenberg, F. Clin. Infect. Dis. (1996) [Pubmed]
  27. Intrathecal gadolinium-enhanced MR myelography and cisternography: a pilot study in human patients. Zeng, Q., Xiong, L., Jinkins, J.R., Fan, Z., Liu, Z. AJR. American journal of roentgenology. (1999) [Pubmed]
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