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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Effects induced by the electrical stimulation of the nucleus raphe dorsalis upon hypothalamic release of 5-hydroxyindole compounds and sleep parameters in the rat.

Electrical stimulation (30 min; pulse 0.5 ms, 150 microA, 20 Hz) of the antero-dorsal part of the nucleus raphe dorsalis (n.RD) induces in the basal hypothalamus (n. arcuate and surrounding areas) a large axonal release of 5-hydroxyindole compounds (5-OHLes; about +300%) measured by means of voltammetric technique. During such a release, evidence for a direct detection of serotonin (5-HT) is reported. The above stimulation induces also marked aversive behaviors together with prolonged polygraphic arousal. Three hours later, a significant paradoxical sleep (PS) rebound occurs. Both the 5-OHLes release and the PS rebound observed after n.RD stimulation are suppressed by a p-chlorophenylalanine (PCPA) pretreatment of the animals. The 5-HT-hypnogenic factor dependence of the PS rebound observed after n.RD stimulation is discussed.[1]

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