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Chemical Compound Review

PubChem7263     1H-indol-5-ol

Synonyms: zlchem 359, INDOL-5-OL, SureCN50566, AGN-PC-0DBEUX, CHEMBL404923, ...
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Disease relevance of INDOL-5-OL


Psychiatry related information on INDOL-5-OL


High impact information on INDOL-5-OL


Chemical compound and disease context of INDOL-5-OL


Biological context of INDOL-5-OL


Anatomical context of INDOL-5-OL

  • In this study, we have investigated the effects of 5-hydroxyindole (5-HI), a positive modulator of the alpha7 nAChR, on GABAergic activity in hippocampal CA1 stratum radiatum interneurons in acute rat brain slices [17].
  • In brief, noxious stimulation was found to decrease 5-hydroxyindole signal in the nucleus raphe magnus; morphine enhanced or attenuated this decrease in the anesthesized rat [18].
  • During the initial phase of group formation, 5-hydroxyindole acetic acid, the metabolite of serotonin, increases in the cerebrospinal fluid of monkeys which become subordinate (all groups), but decreases in monkeys which become dominant (two out of three groups) and shows no changes in intermediate-ranking animals (five out of seven) [19].
  • 5-hydroxyindole causes convulsions and increases transmitter release in the CA1 region of the rat hippocampus [20].
  • The effects of 5-hydroxyindole (5-HI) have been investigated on human alpha 7 nicotinic acetylcholine receptors (nAChRs) expressed in Xenopus oocytes and GH4 cells, on native alpha 7 nAChRs expressed by IMR-32 cells and on alpha 7 nAChR-mediated events in mossy fibre-granule cell synapses in rat cerebellar slices [21].

Associations of INDOL-5-OL with other chemical compounds


Gene context of INDOL-5-OL


Analytical, diagnostic and therapeutic context of INDOL-5-OL


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