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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Stereoselective inhibition by D- and L-alanine of phencyclidine-induced locomotor stimulation in the rat.

Bilateral injection of D-alanine, but not L-alanine, (10-100 micrograms per side for each amino acid) into the lateral ventricle reduced the increasing effect of phencyclidine (PCP, 10 mg/kg, given intraperitoneally) on locomotor activity in the rat in a dose dependent manner. This stereoselectivity agrees with the potency of these agents as agonists for the strychnine-insensitive glycine receptor in the N-methyl-D-aspartate receptor complex, suggesting that stimulation of the allosteric regulation site may antagonize the ability of PCP to produce hyperactivity.[1]

References

  1. Stereoselective inhibition by D- and L-alanine of phencyclidine-induced locomotor stimulation in the rat. Tanii, Y., Nishikawa, T., Hashimoto, A., Takahashi, K. Brain Res. (1991) [Pubmed]
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