The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Allosteric Regulation

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Allosteric Regulation


High impact information on Allosteric Regulation


Chemical compound and disease context of Allosteric Regulation


Biological context of Allosteric Regulation


Anatomical context of Allosteric Regulation


Associations of Allosteric Regulation with chemical compounds

  • The flip and flop splice variants of AMPA receptors show strikingly different sensitivity to allosteric regulation by cyclothiazide; heteromers assembled from GluR-A and GluR-B also exhibit splice variant-dependent differences in efficacy for activation by glutamate and kainate [26].
  • Ligand-induced formation of an SDS-resistant dimer is unprecedented and suggests a novel role for tetrahydrobiopterin and L-arginine in the allosteric regulation of protein subunit interactions [27].
  • The discovery of the Na(+)-dependent allosteric regulation in serine proteases makes it possible to control catalytic activity and specificity in this class of enzymes in a way never considered before [28].
  • The generation of these revertant enzymes provides additional structure-function information on the allosteric regulation of higher plant ADP-glucose pyrophosphorylases and validates a strategy for developing novel variants of the enzyme that may be useful in manipulating starch biosynthesis in higher plants [29].
  • The mutant enzyme and alkaline phosphatase-treated wild-type enzyme are more active than untreated wild-type enzyme and less sensitive to inhibition by saturating AdoMet, indicating that phosphorylation at Thr-34 is critical for allosteric regulation of human MTHFR activity by AdoMet [30].

Gene context of Allosteric Regulation


Analytical, diagnostic and therapeutic context of Allosteric Regulation


  1. von Willebrand disease type B: a missense mutation selectively abolishes ristocetin-induced von Willebrand factor binding to platelet glycoprotein Ib. Rabinowitz, I., Tuley, E.A., Mancuso, D.J., Randi, A.M., Firkin, B.G., Howard, M.A., Sadler, J.E. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  2. Evidence for the allosteric regulation of glycogen synthesis in the intact Escherichia coli cell. Agreement of the values of the parameters of the Hill equation fitted to data for glycogen synthesis in vivo with the abailable values obtained in vitro with adenosine diphosphoglucose synthetase. Dietzler, D.N., Leckie, M.P., Lais, C.J., Magnani, J.L. J. Biol. Chem. (1975) [Pubmed]
  3. T4 phage ribonucleotide reductase. Allosteric regulation in vivo by thymidine triphosphate. Ji, J.P., Sargent, R.G., Mathews, C.K. J. Biol. Chem. (1991) [Pubmed]
  4. Crystal structure of the reaction complex of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Thermotoga maritima refines the catalytic mechanism and indicates a new mechanism of allosteric regulation. Shumilin, I.A., Bauerle, R., Wu, J., Woodard, R.W., Kretsinger, R.H. J. Mol. Biol. (2004) [Pubmed]
  5. Intramolecular signal transmission in enterobacterial aspartate transcarbamylases II. Engineering co-operativity and allosteric regulation in the aspartate transcarbamylase of Erwinia herbicola. Cunin, R., Rani, C.S., Van Vliet, F., Wild, J.R., Wales, M. J. Mol. Biol. (1999) [Pubmed]
  6. Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation. Milner, J., Medcalf, E.A. Cell (1991) [Pubmed]
  7. Regulation of carbamoyl phosphate synthetase by MAP kinase. Graves, L.M., Guy, H.I., Kozlowski, P., Huang, M., Lazarowski, E., Pope, R.M., Collins, M.A., Dahlstrand, E.N., Earp, H.S., Evans, D.R. Nature (2000) [Pubmed]
  8. A third mode of integrin antagonism. Kelly, T.A. Immunity (2003) [Pubmed]
  9. Allosteric regulation of Hsp70 chaperones by a proline switch. Vogel, M., Bukau, B., Mayer, M.P. Mol. Cell (2006) [Pubmed]
  10. Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain. Radhakrishnan, A., Sun, L.P., Kwon, H.J., Brown, M.S., Goldstein, J.L. Mol. Cell (2004) [Pubmed]
  11. Serine 948 and threonine 1042 are crucial residues for allosteric regulation of Escherichia coli carbamoylphosphate synthetase and illustrate coupling effects of activation and inhibition pathways. Delannay, S., Charlier, D., Tricot, C., Villeret, V., Piérard, A., Stalon, V. J. Mol. Biol. (1999) [Pubmed]
  12. Site-directed mutagenesis of the regulatory domain of Escherichia coli carbamoyl phosphate synthetase identifies crucial residues for allosteric regulation and for transduction of the regulatory signals. Fresquet, V., Mora, P., Rochera, L., Ramón-Maiques, S., Rubio, V., Cervera, J. J. Mol. Biol. (2000) [Pubmed]
  13. Crystal structures of Escherichia coli glycerol kinase variant S58-->W in complex with nonhydrolyzable ATP analogues reveal a putative active conformation of the enzyme as a result of domain motion. Bystrom, C.E., Pettigrew, D.W., Branchaud, B.P., O'Brien, P., Remington, S.J. Biochemistry (1999) [Pubmed]
  14. On the multiple functional roles of the active site histidine in catalysis and allosteric regulation of Escherichia coli glucosamine 6-phosphate deaminase. Montero-Morán, G.M., Lara-González, S., Alvarez-Añorve, L.I., Plumbridge, J.A., Calcagno, M.L. Biochemistry (2001) [Pubmed]
  15. Involvement of the central loop of the lactose permease of Escherichia coli in its allosteric regulation by the glucose-specific enzyme IIA of the phosphoenolpyruvate-dependent phosphotransferase system. Hoischen, C., Levin, J., Pitaknarongphorn, S., Reizer, J., Saier, M.H. J. Bacteriol. (1996) [Pubmed]
  16. Cloning and characterization of the R1 and R2 subunits of ribonucleotide reductase from Trypanosoma brucei. Hofer, A., Schmidt, P.P., Gräslund, A., Thelander, L. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  17. Binding of bisubstrate analog promotes large structural changes in the unregulated catalytic trimer of aspartate transcarbamoylase: implications for allosteric regulation induced cell migration. Endrizzi, J.A., Beernink, P.T., Alber, T., Schachman, H.K. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  18. The mechanism of velocity modulated allosteric regulation in D-3-phosphoglycerate dehydrogenase. Site-directed mutagenesis of effector binding site residues. Al-Rabiee, R., Zhang, Y., Grant, G.A. J. Biol. Chem. (1996) [Pubmed]
  19. Pleiotropic regulation of central carbohydrate metabolism in Escherichia coli via the gene csrA. Sabnis, N.A., Yang, H., Romeo, T. J. Biol. Chem. (1995) [Pubmed]
  20. Cell cycle-dependent regulation of pyrimidine biosynthesis. Sigoillot, F.D., Berkowski, J.A., Sigoillot, S.M., Kotsis, D.H., Guy, H.I. J. Biol. Chem. (2003) [Pubmed]
  21. Molecular determinants of cardiac Ca2+ channel pharmacology. Subunit requirement for the high affinity and allosteric regulation of dihydropyridine binding. Wei, X., Pan, S., Lang, W., Kim, H., Schneider, T., Perez-Reyes, E., Birnbaumer, L. J. Biol. Chem. (1995) [Pubmed]
  22. Coordinated regulation of glutamine:fructose-6-phosphate amidotransferase activity by insulin, glucose, and glutamine. Role of hexosamine biosynthesis in enzyme regulation. Traxinger, R.R., Marshall, S. J. Biol. Chem. (1991) [Pubmed]
  23. Direct interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity. Ju, H., Zou, R., Venema, V.J., Venema, R.C. J. Biol. Chem. (1997) [Pubmed]
  24. A paradox: the 5-HT2-receptor antagonist ketanserin restores the 5-HT-induced contraction depressed by methysergide in large coronary arteries of calf. Allosteric regulation of 5-HT2-receptors. Kaumann, A.J., Frenken, M. Naunyn Schmiedebergs Arch. Pharmacol. (1985) [Pubmed]
  25. Reconstitution of the skeletal muscle dihydropyridine receptor. Functional interaction among alpha 1, beta, gamma and alpha 2 delta subunits. Suh-Kim, H., Wei, X., Klos, A., Pan, S., Ruth, P., Flockerzi, V., Hofmann, F., Perez-Reyes, E., Birnbaumer, L. Recept. Channels (1996) [Pubmed]
  26. Structural determinants of allosteric regulation in alternatively spliced AMPA receptors. Partin, K.M., Bowie, D., Mayer, M.L. Neuron (1995) [Pubmed]
  27. Structural analysis of porcine brain nitric oxide synthase reveals a role for tetrahydrobiopterin and L-arginine in the formation of an SDS-resistant dimer. Klatt, P., Schmidt, K., Lehner, D., Glatter, O., Bächinger, H.P., Mayer, B. EMBO J. (1995) [Pubmed]
  28. Rational engineering of activity and specificity in a serine protease. Dang, Q.D., Guinto, E.R., di Cera, E. Nat. Biotechnol. (1997) [Pubmed]
  29. Generation of up-regulated allosteric variants of potato ADP-glucose pyrophosphorylase by reversion genetics. Greene, T.W., Kavakli, I.H., Kahn, M.L., Okita, T.W. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  30. Regulation of human methylenetetrahydrofolate reductase by phosphorylation. Yamada, K., Strahler, J.R., Andrews, P.C., Matthews, R.G. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  31. Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo. Kaeser, M.D., Iggo, R.D. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  32. Coevolution of transcriptional and allosteric regulation at the chorismate metabolic branch point of Saccharomyces cerevisiae. Krappmann, S., Lipscomb, W.N., Braus, G.H. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  33. The nucleotide switch in Cdc42 modulates coupling between the GTPase-binding and allosteric equilibria of Wiskott-Aldrich syndrome protein. Leung, D.W., Rosen, M.K. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  34. Single point mutations in either gene encoding the subunits of the heterooctameric yeast phosphofructokinase abolish allosteric inhibition by ATP. Rodicio, R., Strauss, A., Heinisch, J.J. J. Biol. Chem. (2000) [Pubmed]
  35. The allosteric regulation of pyruvate kinase. Valentini, G., Chiarelli, L., Fortin, R., Speranza, M.L., Galizzi, A., Mattevi, A. J. Biol. Chem. (2000) [Pubmed]
  36. Difference FTIR studies reveal nitrogen-containing amino acid side chains are involved in the allosteric regulation of RecA. Schwartz, C.M., Drown, P.M., MacDonald, G. Biochemistry (2005) [Pubmed]
WikiGenes - Universities