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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Glutathione and cellular response of ACNU-resistant rat glioma sublines to drugs and radiation.

Three ACNU-resistant sublines (R1, R3 and R12) from rat glioma 9L cells showed cross-resistance to vinblastine, adriamycin, and VP-16. Among these, the R3 subline also acquired radioresistance under aerobic conditions. Total glutathione levels in these sublines were elevated 2- to 3-fold. Treatment of the cells with BSO, a specific inhibitor of GSH synthesis, resulted in decreased intracellular total glutathione levels in all 4 cell lines to about 10% of control levels. However, sensitivity to radiation or to chemicals did not change accordingly. Treatment of 9L cells with OTZ, a precursor of cysteine, resulted in a rise in intracellular GSH levels but it did not correlate with sensitivity to X-ray or to ACNU. These results suggest that, in terms of cellular sensitivity to radiation or ACNU, total glutathione level alone cannot serve as a predictive indicator.[1]

References

  1. Glutathione and cellular response of ACNU-resistant rat glioma sublines to drugs and radiation. Saito, Y., Nakada, Y., Hotta, T., Mikami, T., Kurisu, K., Yamada, K., Kiya, K., Kawamoto, K., Uozumi, T. Int. J. Cancer (1991) [Pubmed]
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