Chemical Compound Review:
NIMUSTINE 3-[(4-amino-2-methyl- pyrimidin-5...
Synonyms:
Nimustin, Nimustina, Nimustinum, Lopac-N-8659, CHEMBL136737, ...
- Chemoprotective effects of KF41399, a derivative of carbazole compounds, on nimustine-induced thrombocytopenia. Shiotsu, Y., Yamashita, K., Kanai, F., Ikuina, Y., Murakata, C., Teramura, M., Mizoguchi, H., Tamaoki, T., Akinaga, S. Blood (2000)
- Neurotoxicity and pharmacokinetics of intrathecal perfusion of ACNU in dogs. Kochi, M., Kuratsu, J., Mihara, Y., Takaki, S., Inoue, N., Sueyoshi, N., Uemura, S., Ushio, Y. Cancer Res. (1990)
- Neuro-Oncology Working Group 01 trial of nimustine plus teniposide versus nimustine plus cytarabine chemotherapy in addition to involved-field radiotherapy in the first-line treatment of malignant glioma. Weller, M., Müller, B., Koch, R., Bamberg, M., Krauseneck, P. J. Clin. Oncol. (2003)
- A comparison of the biological and biochemical properties of 1-(4-amino-2-methylpyrimidin-5-yl)methyl-3-(2-chloroethyl)-3-nitrosourea and 2-[3-(2-chloroethyl)-3-nitrosoureido]-D-glucopyranose. Nagourney, R.A., Fox, P., Schein, P.S. Cancer Res. (1978)
- Transient induction of the MRP/GS-X pump and gamma-glutamylcysteine synthetase by 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3- nitrosourea in human glioma cells. Gomi, A., Shinoda, S., Masuzawa, T., Ishikawa, T., Kuo, M.T. Cancer Res. (1997)
- The DNA repair protein O6-methylguanine-DNA methyltransferase protects against skin tumor formation induced by antineoplastic chloroethylnitrosourea. Becker, K., Gregel, C.M., Kaina, B. Cancer Res. (1997)
- Experimental combination chemotherapy of ACNU and 5-FU against cultured glioma model (spheroid) and subcutaneous rat glioma. Kitahara, M., Katakura, R., Suzuki, J., Sasaki, T. Int. J. Cancer (1987)
- Glutathione and cellular response of ACNU-resistant rat glioma sublines to drugs and radiation. Saito, Y., Nakada, Y., Hotta, T., Mikami, T., Kurisu, K., Yamada, K., Kiya, K., Kawamoto, K., Uozumi, T. Int. J. Cancer (1991)
- Artificial control of nuclear translocation of DNA repair methyltransferase. Ishibashi, T., Nakabeppu, Y., Sekiguchi, M. J. Biol. Chem. (1994)
- Adenovirus-mediated p16 gene transfer prevents drug-induced cell death through G1 arrest in human glioma cells. Hama, S., Heike, Y., Naruse, I., Takahashi, M., Yoshioka, H., Arita, K., Kurisu, K., Goldman, C.K., Curiel, D.T., Saijo, N. Int. J. Cancer (1998)
- Influence of O6-methylguanine-DNA methyltransferase activity on chloroethylnitrosourea chemotherapy in brain tumors. Mineura, K., Izumi, I., Watanabe, K., Kowada, M. Int. J. Cancer (1993)
- Isolation of two chloroethylnitrosourea-sensitive Chinese hamster cell lines. Hata, H., Numata, M., Tohda, H., Yasui, A., Oikawa, A. Cancer Res. (1991)
- Central nervous system toxicity and cerebrospinal fluid pharmacokinetics of intraventricular 3-[(4-amino-2-methyl-5-pyrimidinyl)ethyl]-1-(2-chloroethyl)-1-nitro soureas and other nitrosoureas in beagles. Levin, V.A., Byrd, D., Campbell, J., Giannini, D.D., Borcich, J.K., Davis, R.L. Cancer Res. (1985)
- Most effective route of administration and utilization of high-dose chemotherapy with bone marrow transplantation in rats. Mizushima, Y., Morikage, T., Sasaki, K., Yano, S. Cancer Res. (1989)
- Selective cytotoxicity of haloethylnitrosoureas in a carcinoma cell line resistant to bifunctional nitrogen mustards. Tew, K.D., Wang, A.L. Mol. Pharmacol. (1982)
- Enhancing effect of O6-alkylguanine derivatives on chloroethylnitrosourea cytotoxicity toward tumor cells. Mineura, K., Izumi, I., Watanabe, K., Kowada, M., Kohda, K., Koyama, K., Terashima, I., Ikenaga, M. Int. J. Cancer (1994)
- Retroviral coexpression of two different types of drug resistance genes to protect normal cells from combination chemotherapy. Suzuki, M., Sugimoto, Y., Tsukahara, S., Okochi, E., Gottesman, M.M., Tsuruo, T. Clin. Cancer Res. (1997)
- The effect of o6-methylguanine-DNA methyltransferase (MGMT) and mismatch repair gene (hMLH1) status on the sensitivity to alkylating agent 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea(ACNU) in gallbladder carcinoma cells. Sato, K., Kitajima, Y., Koga, Y., Miyazaki, K. Anticancer Res. (2005)
- Suppression of Cdc2 dephosphorylation at the tyrosine 15 residue during nitrosourea-induced G2M phase arrest in glioblastoma cell lines. Nakamizo, A., Inamura, T., Inoha, S., Amano, T., Ochi, H., Ikezaki, K., Fukui, M. J. Neurooncol. (2002)
- p53-independent WAF1 induction by ACNU in human glioblastoma cells. Aoki, H., Ohnishi, K., Wang, X., Takahashi, A., Ohnishi, T., Nakamura, M., Sakaki, T. Mol. Carcinog. (1998)
- Significance of DNA cross-links on 1-(4-amino-2-methylpyrimidin-5-yl)methyl-3-(2-chloroethyl)-3- nitrosourea (ACNU)-induced cytotoxicity against ACNU-sensitive and -resistant lines of 9L rat glioma cells. Kokunai, T., Tamaki, N., Matsumoto, S. J. Natl. Cancer Inst. (1987)
- Hypersensitivity of human tumor xenografts lacking O6-alkylguanine-DNA alkyltransferase to the anti-tumor agent 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitros ourea. Fujio, C., Chang, H.R., Tsujimura, T., Ishizaki, K., Kitamura, H., Ikenaga, M. Carcinogenesis (1989)