Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Laupland, K.B. et al.

Kevin B. Laupland, Deirdre L. Church, Jeanne Vidakovich, Melissa Mucenski, Johann D. D. Pitout,

Community-onset extended-spectrum beta-lactamase (ESBL) producing Escherichia coli: importance of international travel.

OBJECTIVES: Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli have emerged as significant causes of community-onset disease. We sought to identify risk factors for acquiring community-onset ESBL-producing E. coli. METHODS: Prospective, population-based surveillance for ESBL-producing E. coli was performed in the Calgary Health Region (population 1.2 million), Canada during a two-year period. RESULTS: 247 patients were identified; 177 (72%; 7.6 per 100,000/year) were community acquired, and 70 (28%; 3.0 per 100,000/year) were healthcare associated. The acquisition risk increased with advancing age. Females were at higher risk as compared to males [relative risk (RR) 4.3; 95% confidence interval (CI), 3.1-6.1] as were urban as compared to rural residents (RR 2.2; 95% CI, 1.4-3.6). A number of co-morbidities increased risk (RR; 95% CI) including requirement for hemodialysis (56.3; 15.1-147.4), urinary incontinence (21.7; 15.0-30.9), cancer (11.1; 7.0-17.0), heart disease (6.5; 4.3-9.7), and diabetes (4.4; 2.6-7.1). Overseas travel overall increased the risk (5.7; 4.1-7.8) and was highest in travelers to India (145.6; 77.7-252.1), the Middle East (18.1; 8.1-35.2), and Africa (7.7; 2.8-17.2). CONCLUSIONS: Advancing age, female gender, co-morbid medical conditions, and foreign travel are important risk factors for developing community-onset ESBL-producing E. coli infections in our region. Emergence of anti-microbial-resistant pathogens is a global concern.[1]

References

Community-onset extended-spectrum beta-lactamase (ESBL) producing Escherichia coli: importance of international travel. Laupland, K.B., Church, D.L., Vidakovich, J., Mucenski, M., Pitout, J.D. J. Infect. (2008) [Pubmed]

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