Dose-response meta-analysis of silica and lung cancer.
OBJECTIVE: To examine the association between occupational exposure to silica and lung cancer from a systematic review (and meta-analysis) of the epidemiologic literature, with special reference to the methodological quality of observational studies. METHODS: We searched Medline, Toxline, BIOSIS, and Embase (1966-December 2007) for original articles published in any language. Observational studies (cohort and case-control studies) were selected if they reported the result of dose-response analyses relating lung cancer to occupational exposure to silica after appropriate adjustment for smoking. RESULTS: Ten studies (4 cohort studies and 6 case-control studies) met the inclusion criteria of the meta-analysis, nine of which contributing to the main analysis (dose-response analysis, no lag time). We found increasing risk of lung cancer with increasing cumulative exposure to silica, with heterogeneity across studies however. Posthoc analyses identified a set of seven more homogeneous studies. Their meta-analysis resulted in a dose-response curve that was not different from that obtained in the main analysis. CONCLUSION: Silica is a lung carcinogen. This increased risk is particularly apparent when the cumulative exposure to silica is well beyond that resulting from exposure to the recommended limit concentration for a prolonged period of time.[1]References
- Dose-response meta-analysis of silica and lung cancer. Lacasse, Y., Martin, S., Gagné, D., Lakhal, L. Cancer. Causes. Control (2009) [Pubmed]
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