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Chemical Compound Review

Aerosil     dioxosilane

Synonyms: Tridymite, KIESELGUHR, Quartz, Silica, Cristobalite, ...
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Disease relevance of Silica


Psychiatry related information on Silica

  • Intermediate level motion and form perceptions were measured using global dot motion stimuli and Glass patterns, respectively [6].
  • In support of this possibility, deficits in the perception of concentric Glass patterns have recently been linked to prosopagnosia [7].
  • Perception of Glass pattern structure with stereopsis [8].
  • The reaction time (RT) regression lines had steeper negative slopes than those attained by Jagacinski, Repperger, Moran, Ward, and Glass (1980), who used an isotonic controller [9].
  • Results were integrated into Glass' model of the role of individual differences in need for personal control in the coping process, and discussed in terms of their implications for understanding the biopsychosocial mechanisms through which some Type A behaviors might increase an individual's risk of coronary heart disease [10].

High impact information on Silica

  • There, the BMP ligand Glass bottom boat activates the Wishful thinking receptor, initiating a retrograde BMP signal in the Tv neuron [11].
  • Structures resembling remarkably preserved bacterial and cyanobacterial microfossils from about 3,465-million-year-old Apex cherts of the Warrawoona Group in Western Australia currently provide the oldest morphological evidence for life on Earth and have been taken to support an early beginning for oxygen-producing photosynthesis [12].
  • Results of a mathematical analysis of models of hematopoietic systems introduced by Mackey and Glass are given [13].
  • "The Glass Ceiling for Women in the Life Sciences Meeting", organized by the European Molecular Biology Organization (EMBO), was held on 22-23 June 2001 in Heidelberg, Germany [14].
  • Silica particles (quartz dust) are toxic to macrophages after their uptake into these cells [15].

Chemical compound and disease context of Silica


Biological context of Silica


Anatomical context of Silica

  • A preparation of fibrin precipitated over a solid Celite (diatomaceous earth) matrix that selectively binds 50-70% of the plasminogen activator present in human blood plasma is described [26].
  • Exposure of rats to aerosols of respirable cristobalite for 8 days led to a rapid influx of neutrophils and macrophages into alveolar and tissue compartments of the lung followed by a more gradual accumulation of T lymphocytes [27].
  • The thyroid receptor binding element (TBE) does not contain any repeats or palindromes but is composed of two different domains, one of which is very similar to the half-palindromic motif described by Glass et al [28].
  • In contrast to peritoneal exudate cells (PEC) or splenic adherent cells, DC from thoracic duct lymph (TD-DC) or from spleen did not secrete detectable amounts of IL 1 on stimulation with LPS/Silica [29].
  • Methods: Silica particles (2-200 mug/hamster) were intratracheally instilled, and experimental thrombosis in photochemically induced femoral vein lesions was assessed 24 hours later, in association with cellular infiltration in the lung [30].

Associations of Silica with other chemical compounds

  • With the use of a novel Silica Sep Pak sterol separation procedure, we demonstrated that 60-80% of the acetonesoluble lipid radioactivity in [5-3H]mevalonate-labeled CHO-215 cells was incorporated into acidic sterols [31].
  • Dispersions of silica spheres (aerosil) in octylcyanobiphenyl (8CB) liquid crystal were investigated with deuteron NMR [32].
  • Diacerein was significantly superior to placebo during the active treatment phase (Glass score, 1.50 [95% confidence interval, 0.80-2.20]) [33].
  • Steady-state mRNA levels and immunoreactive protein for manganese-containing superoxide dismutase (MnSOD) were assayed in rat lungs after subchronic inhalation of the fibrogenic silicon dioxide, cristobalite, or preparations of titanium dioxide (TiO2) of different inflammatory and fibrogenic potential [16].
  • The solution for extracting C-protein contained 10 mM EDTA, 31 mM Na2HPO2, 124 mM NaH2PO4, pH 5.9 (Offer et al., 1973; Hartzell and Glass, 1984) [34].

Gene context of Silica


Analytical, diagnostic and therapeutic context of Silica


  1. Images in clinical medicine. Sand as a foreign body. Petitti, N. N. Engl. J. Med. (1997) [Pubmed]
  2. Infectious diseases. Sand fly saliva may be key to new vaccine. Enserink, M. Science (2001) [Pubmed]
  3. Silica dust and lung cancer: results from the Nordic occupational mortality and cancer incidence registers. Lynge, E., Kurppa, K., Kristofersen, L., Malker, H., Sauli, H. J. Natl. Cancer Inst. (1986) [Pubmed]
  4. Hepatic silicosis, cirrhosis, and liver tumors in mice and hamsters: studies of transforming growth factor beta expression. Williams, A.O., Knapton, A.D. Hepatology (1996) [Pubmed]
  5. MARCO Mediates Silica Uptake and Toxicity in Alveolar Macrophages from C57BL/6 Mice. Hamilton, R.F., Thakur, S.A., Mayfair, J.K., Holian, A. J. Biol. Chem. (2006) [Pubmed]
  6. Vernier acuity is normal in migraine, whereas global form and global motion perception are not. McKendrick, A.M., Badcock, D.R., Gurgone, M. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  7. Concentric orientation summation in human form vision. Wilson, H.R., Wilkinson, F., Asaad, W. Vision Res. (1997) [Pubmed]
  8. Perception of Glass pattern structure with stereopsis. Earle, D.C. Perception. (1985) [Pubmed]
  9. Fitts' law with an isometric controller: effects of order of control and control-display gain. Kantowitz, B.H., Elvers, G.C. Journal of motor behavior. (1988) [Pubmed]
  10. Association of type A behavior and its components to ways of coping with stress. Hart, K.E. Journal of psychosomatic research. (1988) [Pubmed]
  11. Specification of neuropeptide cell identity by the integration of retrograde BMP signaling and a combinatorial transcription factor code. Allan, D.W., St Pierre, S.E., Miguel-Aliaga, I., Thor, S. Cell (2003) [Pubmed]
  12. Questioning the evidence for Earth's oldest fossils. Brasier, M.D., Green, O.R., Jephcoat, A.P., Kleppe, A.K., Van Kranendonk, M.J., Lindsay, J.F., Steele, A., Grassineau, N.V. Nature (2002) [Pubmed]
  13. Control of oscillations in hematopoiesis. Kazarinoff, N.D., van denDriessche, P. Science (1979) [Pubmed]
  14. Breaking glass? Wilson, E.K. Trends Biochem. Sci. (2001) [Pubmed]
  15. Uptake of toxic silica particles by isolated rat liver macrophages (Kupffer cells) is receptor mediated and can be blocked by competition. Kolb-Bachofen, V. J. Clin. Invest. (1992) [Pubmed]
  16. Increased expression of manganese-containing superoxide dismutase in rat lungs after inhalation of inflammatory and fibrogenic minerals. Janssen, Y.M., Marsh, J.P., Driscoll, K.E., Borm, P.J., Oberdörster, G., Mossman, B.T. Free Radic. Biol. Med. (1994) [Pubmed]
  17. Development and application of new positively charged filters for recovery of bacteriophages from water. Borrego, J.J., Cornax, R., Preston, D.R., Farrah, S.R., McElhaney, B., Bitton, G. Appl. Environ. Microbiol. (1991) [Pubmed]
  18. Use of modified diatomaceous earth for removal and recovery of viruses in water. Farrah, S.R., Preston, D.R., Toranzos, G.A., Girard, M., Erdos, G.A., Vasuhdivan, V. Appl. Environ. Microbiol. (1991) [Pubmed]
  19. Adsorption of Streptococcus faecalis on diatomite carriers for use in biotransformations. Anderson, W.A., Bay, P., Legge, R.L., Moo-Young, M. Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986) (1990) [Pubmed]
  20. Proposals for wastewater treatment by applying flocculating activity of cross-linked poly-gamma-glutamic acid. Taniguchi, M., Kato, K., Shimauchi, A., Ping, X., Nakayama, H., Fujita, K., Tanaka, T., Tarui, Y., Hirasawa, E. J. Biosci. Bioeng. (2005) [Pubmed]
  21. Partial purification and characterization of contact activation cofactor. Schiffman, S., Lee, P. J. Clin. Invest. (1975) [Pubmed]
  22. The expanding transcriptome: the genome as the 'Book of Sand'. Mendes Soares, L.M., Valcárcel, J. EMBO J. (2006) [Pubmed]
  23. Genetic dissection of behavior: modulation of locomotion by light in the Drosophila melanogaster larva requires genetically distinct visual system functions. Busto, M., Iyengar, B., Campos, A.R. J. Neurosci. (1999) [Pubmed]
  24. Increased manganese superoxide dismutase protein in type II epithelial cells of rat lungs after inhalation of crocidolite asbestos or cristobalite silica. Holley, J.A., Janssen, Y.M., Mossman, B.T., Taatjes, D.J. Am. J. Pathol. (1992) [Pubmed]
  25. Occupational exposure to crystalline silica and risk of systemic lupus erythematosus: a population-based, case-control study in the southeastern United States. Parks, C.G., Cooper, G.S., Nylander-French, L.A., Sanderson, W.T., Dement, J.M., Cohen, P.L., Dooley, M.A., Treadwell, E.L., St Clair, E.W., Gilkeson, G.S., Hoppin, J.A., Savitz, D.A. Arthritis Rheum. (2002) [Pubmed]
  26. Rapid purification of a high-affinity plasminogen activator from human blood plasma by specific adsorption on fibrin/Celite. Husain, S.S., Lipinski, B., Greuwich, V. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  27. Biphasic cellular and tissue response of rat lungs after eight-day aerosol exposure to the silicon dioxide cristobalite. Absher, M.P., Trombley, L., Hemenway, D.R., Mickey, R.M., Leslie, K.O. Am. J. Pathol. (1989) [Pubmed]
  28. Characterization of an unusual thyroid response unit in the promoter of the human placental lactogen gene. Voz, M.L., Peers, B., Belayew, A., Martial, J.A. J. Biol. Chem. (1991) [Pubmed]
  29. Membrane-associated IL 1-like activity on rat dendritic cells. Nagelkerken, L.M., van Breda Vriesman, P.J. J. Immunol. (1986) [Pubmed]
  30. Silica particles enhance peripheral thrombosis: key role of lung macrophage-neutrophil cross-talk. Nemmar, A., Nemery, B., Hoet, P.H., Van Rooijen, N., Hoylaerts, M.F. Am. J. Respir. Crit. Care Med. (2005) [Pubmed]
  31. Sterol-mediated regulation of mevalonic acid synthesis. Accumulation of 4-carboxysterols as the predominant sterols synthesized in a Chinese hamster ovary cell cholesterol auxotroph (mutant 215). Plemenitas, A., Havel, C.M., Watson, J.A. J. Biol. Chem. (1990) [Pubmed]
  32. Aerosil dispersed in a liquid crystal: magnetic order and random silica disorder. Jin, T., Finotello, D. Phys. Rev. Lett. (2001) [Pubmed]
  33. A meta-analysis of controlled clinical studies with diacerein in the treatment of osteoarthritis. Rintelen, B., Neumann, K., Leeb, B.F. Arch. Intern. Med. (2006) [Pubmed]
  34. Alterations in Ca2+ sensitive tension due to partial extraction of C-protein from rat skinned cardiac myocytes and rabbit skeletal muscle fibers. Hofmann, P.A., Hartzell, H.C., Moss, R.L. J. Gen. Physiol. (1991) [Pubmed]
  35. Crucial role of interleukin-1beta and nitric oxide synthase in silica-induced inflammation and apoptosis in mice. Srivastava, K.D., Rom, W.N., Jagirdar, J., Yie, T.A., Gordon, T., Tchou-Wong, K.M. Am. J. Respir. Crit. Care Med. (2002) [Pubmed]
  36. Silica-induced chemokine expression in alveolar type II cells is mediated by TNF-alpha. Barrett, E.G., Johnston, C., Oberdörster, G., Finkelstein, J.N. Am. J. Physiol. (1998) [Pubmed]
  37. Genetic studies on the beta subunit of Escherichia coli RNA polymerase. II. Evidence that large N-terminal amber fragments of the beta subunit interfere with RNA polymerase function. Nene, V., Glass, R.E. Mol. Gen. Genet. (1982) [Pubmed]
  38. Regulation of ICAM-1 expression in mouse macrophages. Hubbard, A.K., Giardina, C. Inflammation (2000) [Pubmed]
  39. Selective hyperexpression of c-jun oncoprotein by glass fiber- and silica-transformed BALB/c-3T3 cells. Gao, H., Brick, J., Ong, S., Miller, M., Whong, W.Z., Ong, T. Cancer Lett. (1997) [Pubmed]
  40. Increased renal catabolism of 1,25-dihydroxyvitamin D3 in murine X-linked hypophosphatemic rickets. Tenenhouse, H.S., Yip, A., Jones, G. J. Clin. Invest. (1988) [Pubmed]
  41. Detection of aflatoxin B1 in serum samples of male Japanese subjects by radioimmunoassay and high-performance liquid chromatography. Tsuboi, S., Nakagawa, T., Tomita, M., Seo, T., Ono, H., Kawamura, K., Iwamura, N. Cancer Res. (1984) [Pubmed]
  42. Animal model of human disease. Pulmonary alveolar lipo-proteinosis. Animal model: Silica-induced pulmonary alveolar lipo-proteinosis. Heppleston, A.G. Am. J. Pathol. (1975) [Pubmed]
  43. Alveolar type II cell response in rats exposed to aerosols of alpha-cristobalite. Low, R.B., Leslie, K.O., Hemenway, D.R., Absher, M., Adler, K.B., Giancola, M.S., Vacek, P.M. Am. J. Pathol. (1990) [Pubmed]
  44. Fused-silica capillaries for capillary electrophoresis and gas chromatography: inner surface corrosion, within-batch differences, and influence of drawing parameters studied by atomic force microscopy. Kaupp, S., Wätzig, H. Electrophoresis (1999) [Pubmed]
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