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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Lymphedema of the leg associated with rheumatoid arthritis.

A 14-year-old boy with a two year history of seronegative rheumatoid arthritis developed left leg lymphedema and subsequently a severe episode of lymphangitis. The diagnosis of "rheumatoid lymphedema" was confirmed by lymphscintigraphy and conventional lymphography. Treatment consisted of bedrest and antibiotic drugs. When the signs of inflammation had subsided, therapy with corticosteroids was started with improvement of both joint pain and leg swelling. Whereas lymphedema associated with rheumatoid arthritis has been described in the upper limb of adults, to our knowledge this is the first report of the coexistent condition in the lower leg of a child.[1]


  1. Lymphedema of the leg associated with rheumatoid arthritis. Lacroix, H.R., Gruwez, J.A., Casteels-Van Daele, M.C., Dequeker, J. Lymphology. (1991) [Pubmed]
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