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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Arthralgia


Psychiatry related information on Arthralgia

  • The abstemiousness of RA men compared with their OA counterparts was due to a striking increase in joint pain after drinking alcohol (p = 0.004), fear of adverse drug reactions with alcohol, and a widespread belief not expressed by OA men that 'alcohol and arthritis do not mix' [7].
  • OBJECTIVE: To evaluate neurocognitive impairment in patients with persistent arthralgia, fatigue, and subjective memory loss in patients after Lyme disease (post-Lyme syndrome, PLS) [8].
  • Marked improvement of the arthralgia, fever and lethargy was obtained with oral prednisolone [9].

High impact information on Arthralgia


Chemical compound and disease context of Arthralgia


Biological context of Arthralgia


Anatomical context of Arthralgia

  • The main outcome was lupuslike syndrome defined as the occurrence of polyarthritis or polyarthralgia of unknown origin, with negative rheumatoid factor or latex agglutination test, positive or unmeasured antinuclear factor, elevated or unmeasured erythrocyte sedimentation rate, and absence of or unmeasured antinative DNA antibody levels [25].
  • The severity of joint pain correlated with the degree of lower limb deformity (p = 0.011) which, in turn, was related to fasting serum phosphate concentration (r = -0.56, p less than 0.025) and TmP/GFR (r = -0.70, p less than 0.005) [26].
  • However, in the deeper layers of the spinal cord (V-X), there was no such correlation, and stimulation of joint nociceptors and formalin-induced inflammation produced the greatest proportion of Fos/neurokinin-1 co-localization, suggesting a particular role for substance P in the mediation of joint pain and inflammatory hyperalgesia [27].
  • METHODS: We studied 324 serum and 48 synovial fluid (SF) samples from 103 patients with JIA, 36 with RA, and 8 with arthralgia and 11 controls [28].
  • PATIENTS: Twelve patients with malignant neoplasms who presented with arthritis or arthralgias and normal complete blood cell counts and blood smears in whom rheumatologic diagnosis was initially made were compared with 24 children with a final diagnosis of juvenile rheumatoid arthritis [29].

Gene context of Arthralgia

  • This syndrome is an autosomal dominant disorder characterized by recurring episodes of fever, arthralgia, and skin lesions that is caused by mutations in the 55-kd TNFRSF1A gene [30].
  • Elevated IL-10 levels were detected frequently in patients with arthralgia [31].
  • Reduced general joint pain intensity was associated with reduced plasma levels of IL-6 and C-reactive protein [32].
  • In a Phase II and Phase III trial, conducted in moderate-to-severe PsA, etanercept significantly reduced joint pain and swelling and lowered the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) level [33].
  • Additionally, arthralgia, elevated CRP, and elevated rheumatoid factor were seen significantly more frequently in patients with increased MMP-3 levels than in those with normal MMP-3 levels [34].

Analytical, diagnostic and therapeutic context of Arthralgia


  1. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Hoffman, H.M., Mueller, J.L., Broide, D.H., Wanderer, A.A., Kolodner, R.D. Nat. Genet. (2001) [Pubmed]
  2. Fibrin ring granulomas and allopurinol. Stricker, B.H., Blok, A.P., Babany, G., Benhamou, J.P. Gastroenterology (1989) [Pubmed]
  3. Randomised double-blind placebo-controlled study on adverse effects of rubella immunisation in seronegative women. Tingle, A.J., Mitchell, L.A., Grace, M., Middleton, P., Mathias, R., MacWilliam, L., Chalmers, A. Lancet (1997) [Pubmed]
  4. Initial clinical trial of a selective retinoid X receptor ligand, LGD1069. Miller, V.A., Benedetti, F.M., Rigas, J.R., Verret, A.L., Pfister, D.G., Straus, D., Kris, M.G., Crisp, M., Heyman, R., Loewen, G.R., Truglia, J.A., Warrell, R.P. J. Clin. Oncol. (1997) [Pubmed]
  5. Phase III comparative study of high-dose cisplatin versus a combination of paclitaxel and cisplatin in patients with advanced non-small-cell lung cancer. Gatzemeier, U., von Pawel, J., Gottfried, M., ten Velde, G.P., Mattson, K., DeMarinis, F., Harper, P., Salvati, F., Robinet, G., Lucenti, A., Bogaerts, J., Gallant, G. J. Clin. Oncol. (2000) [Pubmed]
  6. The H63D variant in the HFE gene predisposes to arthralgia, chondrocalcinosis and osteoarthritis. Alizadeh, B.Z., Njajou, O.T., Hazes, J.M., Hofman, A., Slagboom, P.E., Pols, H.A., van Duijn, C.M. Ann. Rheum. Dis. (2007) [Pubmed]
  7. Alcohol consumption in arthritic patients: clinical and laboratory studies. Bradlow, A., Mowat, A.G. Ann. Rheum. Dis. (1985) [Pubmed]
  8. Clinical and neurocognitive features of the post Lyme syndrome. Bujak, D.I., Weinstein, A., Dornbush, R.L. J. Rheumatol. (1996) [Pubmed]
  9. Schnitzler's syndrome: report of a case with progression to Waldenström's macroglobulinaemia. Welsh, B., Tate, B. Australas. J. Dermatol. (1999) [Pubmed]
  10. Diffuse pulmonary injury associated with gold treatment. Winterbauer, R.H., Wilske, K.R., Wheelis, R.F. N. Engl. J. Med. (1976) [Pubmed]
  11. Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial. Blackman, M.R., Sorkin, J.D., Münzer, T., Bellantoni, M.F., Busby-Whitehead, J., Stevens, T.E., Jayme, J., O'Connor, K.G., Christmas, C., Tobin, J.D., Stewart, K.J., Cottrell, E., St Clair, C., Pabst, K.M., Harman, S.M. JAMA (2002) [Pubmed]
  12. Risk of chronic arthropathy among women after rubella vaccination. Vaccine Safety Datalink Team. Ray, P., Black, S., Shinefield, H., Dillon, A., Schwalbe, J., Holmes, S., Hadler, S., Chen, R., Cochi, S., Wassilak, S. JAMA (1997) [Pubmed]
  13. Arthropathy in thalassaemia patients receiving deferiprone. Berkovitch, M., Laxer, R.M., Inman, R., Koren, G., Pritzker, K.P., Fritzler, M.J., Olivieri, N.F. Lancet (1994) [Pubmed]
  14. Fever, myalgia, and arthralgia in a patient on captopril and allopurinol. Samanta, A., Burden, A.C. Lancet (1984) [Pubmed]
  15. Glutamine treatment of paclitaxel-induced myalgias and arthralgias. Savarese, D., Boucher, J., Corey, B. J. Clin. Oncol. (1998) [Pubmed]
  16. Use of gabapentin in the prevention of taxane-induced arthralgias and myalgias. Nguyen, V.H., Lawrence, H.J. J. Clin. Oncol. (2004) [Pubmed]
  17. Postchemotherapy rheumatism. Loprinzi, C.L., Duffy, J., Ingle, J.N. J. Clin. Oncol. (1993) [Pubmed]
  18. Minocycline-induced hyperpigmentation masquerading as alkaptonuria in individuals with joint pain. Suwannarat, P., Phornphutkul, C., Bernardini, I., Turner, M., Gahl, W.A. Arthritis Rheum. (2004) [Pubmed]
  19. Effects of doxycycline on progression of osteoarthritis: results of a randomized, placebo-controlled, double-blind trial. Brandt, K.D., Mazzuca, S.A., Katz, B.P., Lane, K.A., Buckwalter, K.A., Yocum, D.E., Wolfe, F., Schnitzer, T.J., Moreland, L.W., Manzi, S., Bradley, J.D., Sharma, L., Oddis, C.V., Hugenberg, S.T., Heck, L.W. Arthritis Rheum. (2005) [Pubmed]
  20. Sulphasalazine: a review of 40 years' experience. Watkinson, G. Drugs (1986) [Pubmed]
  21. Rheumatoid arthritis in African Colombians from Quibdo. Anaya, J.M., Correa, P.A., Mantilla, R.D., Jimenez, F., Kuffner, T., McNicholl, J.M. Semin. Arthritis Rheum. (2001) [Pubmed]
  22. IL1RN genotype as a risk factor for joint pain in hereditary haemochromatosis? Walker, E.J., Riddell, J., Rodgers, H.J., Bassett, M.L., Wilson, S.R., Cavanaugh, J.A. Ann. Rheum. Dis. (2006) [Pubmed]
  23. Evaluation of immunotoxicity induced by single or concurrent exposure to N,N-diethyl-m-toluamide (DEET), pyridostigmine bromide (PYR), and JP-8 jet fuel. Peden-Adam, M.M., Eudaly, J., Eudaly, E., Dudley, A., Zeigler, J., Lee, A., Robbs, J., Gilkeson, G., Keil, D.E. Toxicology and industrial health. (2001) [Pubmed]
  24. Glucosamine sulfate for osteoarthritis. da Camara, C.C., Dowless, G.V. The Annals of pharmacotherapy. (1998) [Pubmed]
  25. Minocycline and lupuslike syndrome in acne patients. Sturkenboom, M.C., Meier, C.R., Jick, H., Stricker, B.H. Arch. Intern. Med. (1999) [Pubmed]
  26. X-linked hypophosphatemia: a clinical, biochemical, and histopathologic assessment of morbidity in adults. Reid, I.R., Hardy, D.C., Murphy, W.A., Teitelbaum, S.L., Bergfeld, M.A., Whyte, M.P. Medicine (Baltimore) (1989) [Pubmed]
  27. Substance P receptor (neurokinin-1)-expressing neurons in lamina I of the spinal cord encode for the intensity of noxious stimulation: a c-Fos study in rat. Doyle, C.A., Hunt, S.P. Neuroscience (1999) [Pubmed]
  28. Autoantibodies in juvenile idiopathic arthritis: glucose-6-phosphate isomerase is not a specific target. Schepp, C.P., Dannecker, L., Haug, M., Kümmerle-Deschner, J., Beck, H., Kötter, I., Holzer, U., Dannecker, G.E. J. Rheumatol. (2004) [Pubmed]
  29. The discriminating value of serum lactate dehydrogenase levels in children with malignant neoplasms presenting as joint pain. Wallendal, M., Stork, L., Hollister, J.R. Archives of pediatrics & adolescent medicine. (1996) [Pubmed]
  30. Genetic analysis as a valuable key to diagnosis and treatment of periodic Fever. Simon, A., van Deuren, M., Tighe, P.J., van der Meer, J.W., Drenth, J.P. Arch. Intern. Med. (2001) [Pubmed]
  31. Elevated serum levels of interleukin 4 (IL-4), IL-10, and IL-13 in patients with systemic sclerosis. Hasegawa, M., Fujimoto, M., Kikuchi, K., Takehara, K. J. Rheumatol. (1997) [Pubmed]
  32. Reduction of temporomandibular joint pain after treatment with a combination of methotrexate and infliximab is associated with changes in synovial fluid and plasma cytokines in rheumatoid arthritis. Kopp, S., Alstergren, P., Ernestam, S., Nordahl, S., Morin, P., Bratt, J. Cells Tissues Organs (Print) (2005) [Pubmed]
  33. Etanercept in psoriatic arthritis. Anandarajah, A.P., Ritchlin, C.T. Expert opinion on biological therapy. (2003) [Pubmed]
  34. Serum matrix metalloproteinase-3 in systemic sclerosis. Jinnin, M., Ihn, H., Asano, Y., Yamane, K., Yazawa, N., Tamaki, K. Arch. Dermatol. Res. (2004) [Pubmed]
  35. Azathioprine hypersensitivity. Case report and review of the literature. Saway, P.A., Heck, L.W., Bonner, J.R., Kirklin, J.K. Am. J. Med. (1988) [Pubmed]
  36. A randomized, placebo-controlled, double-blind comparison of amlodipine and atenolol in patients with essential hypertension. Johnson, B.F., Frishman, W.H., Brobyn, R., Brown, R.D., Reeves, R.L., Wombolt, D.G. Am. J. Hypertens. (1992) [Pubmed]
  37. Safety profile of quinolone antibiotics in the pediatric population. Grady, R. Pediatr. Infect. Dis. J. (2003) [Pubmed]
  38. Self-assessment of disease activity by patients with rheumatoid arthritis. Hanly, J.G., Mosher, D., Sutton, E., Weerasinghe, S., Theriault, D. J. Rheumatol. (1996) [Pubmed]
  39. Patients surviving more than 10 years on haemodialysis. The natural history of the complications of treatment. Harris, S.A., Brown, E.A. Nephrol. Dial. Transplant. (1998) [Pubmed]
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