The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

The effect of subarachnoid lidocaine and combined subarachnoid lidocaine and epidural bupivacaine on electrical sensory thresholds.

Eight patients undergoing abdominal surgery received a combination of spinal anesthesia (catheter at L2-3 level) and epidural anesthesia (catheter at T10-11 level). Sensory thresholds to electrical stimulation were measured at the S1, L1, T10, and T5 levels before injection, after spinal anesthesia, and after the addition of epidural anesthesia. Subarachnoid injections with 5% lidocaine (without dextrose) were given until a T4 sensory level to pinprick was obtained (mean dose, 175 mg lidocaine). The mean sensory thresholds were increased from 2.2 +/- 0.3, 2.4 +/- 0.4, 2.9 +/- 0.4, and 3.8 +/- 0.4 mA to 21.3 +/- 4.3, 13.3 +/- 4.9, 10 +/- 4.4, and 10.6 +/- 4.3 mA, respectively (p less than 0.05 at all levels). The addition of 5 ml 0.5% epidural bupivacaine further increased the mean sensory thresholds to 26.9 +/- 3.1, 21.7 +/- 4.1, 21.3 +/- 4.1, and 17.5 +/- 4.7 mA, respectively (p less than 0.05 at all levels). Combined subarachnoid and epidural local anesthetics provide an enhanced afferent block not obtainable by either technique alone.[1]

References

 
WikiGenes - Universities