Disease relevance of Sensory Thresholds

• We administered either 1 or 3 g/d of pyridoxine (vitamin B6) to five healthy volunteers and repeatedly followed serum pyridoxal phosphate levels, clinical symptoms and signs, quantitative sensory thresholds (QSTs), and sural nerve electrophysiology [1].
• RESULTS: Inflammatory hypersensitivity was selectively attenuated by very low doses of bupivacaine (concentration range. 0.004-0.0625%), which did not affect the sensory threshold in the contralateral uninflamed limb [2].
• CONCLUSION: Our results show that gabapentin reduces rectal sensory thresholds through attenuating rectal sensitivity to distension and enhancing rectal compliance in diarrhoea-predominant irritable bowel syndrome patients [3].
• METHODS: After neurography of sural nerve and determinations of sensory thresholds for vibration, warm and cold on the foot, whole nerve sural nerve biopsy was performed in 10 men with Type 1 diabetes mellitus, 10 with IGT, and 10 with normal glucose tolerance [4].
• CONCLUSIONS: The study indicates that systemic administration of dexamethasone 2 hours before a burn injury does not reduce the inflammatory-mediated changes in quantitative sensory thresholds, pain perception, or skin erythema in humans [5].

Psychiatry related information on Sensory Thresholds

• Intramuscular injections of diazepam or triazolam were given 30 min before session onset; stimulus intensity was randomly varied from trial to trial, and four to five estimates of sensory thresholds and reaction times were obtained throughout each session [6].
• The results showed that the sensory threshold was not modified by diflunisal, but that the pain threshold was significantly increased two and three hours after 500 mg of diflunisal and one, two, and three hours after 1 gm of diflunisal [7].
• Chlordiazepoxide affected neither sensory thresholds nor reaction times over the same dose range; d-methylamphetamine elevated the visual threshold, but did not elevate the auditory threshold or increase reaction times [8].

High impact information on Sensory Thresholds

• The increase in TRVP1 correlated significantly with the decrease in rectal heat (p=0.03) and the distension (p=0.02) sensory thresholds [9].
• PP responses and visceral sensory thresholds were significantly correlated (r = 0.65, p < 0.002) [10].
• An increase of 1 mmol/l in mean fasting blood glucose has an equivalent effect on the sensory threshold to an extra 5 years of age [11].
• In fewer subjects who used capsaicin cream in an open-label study, there was no significant effect on sensory thresholds after up to 32 wk of use [12].
• It was hypothesized that the removal of this intermittent auditory stimulation, simulating in waking subjects the increased sensory thresholds of REM sleep, would decrease the number of topic shifts in spontaneous thought [13].

Chemical compound and disease context of Sensory Thresholds

• Compared with ethanol and petroleum jelly (Vaseline), the topical application of Benzocaine (0, .5, 1, 3, and 5% solutions in 100% ethanol) significantly increased the tactile sensory thresholds on the volar surface of the forearm [14].
• This study sought to characterize the effects of intravenous lidocaine (a sodium channel blocker) on acute sensory thresholds within the painful area and the size of the painful area in patients suffering from CRPS I and II [15].
• Lack of a ketamine effect suggests an absence of n-methyl-d-aspartate receptor involvement in spinal dorsal horn processing of low threshold sensory information [16].
• Pain was reproduced in all 13 patients and at lower (p < 0.05) sensory thresholds after atropine [17].
• Sensory thresholds and the antinociceptive effects of GABA receptor agonists in mice lacking the beta3 subunit of the GABA(A) receptor [18].

Biological context of Sensory Thresholds

• We demonstrated the effects of fluoxetine on intravaginal latency, penile sensory threshold, and variables of sacral evoked response and cortical somatosensorial evoked potential in patients with premature ejaculation [19].
• The time to first postoperative demand for rescue analgesia, pain, tramadol pharmacokinetics, and electrical sensory thresholds at or distant from the incision were studied [20].

Anatomical context of Sensory Thresholds

• METHODS: We used esophageal balloon distention to compare sensory thresholds between nine male and 10 female volunteers with a latex balloon (length 3 cm) positioned 5 cm proximal to the lower esophageal sphincter [21].
• Damage to the peripheral nervous system by neurotoxic agents can result in elevated sensory thresholds [22].

Gene context of Sensory Thresholds

• Findings from clinical and duplex ultrasound scan (DU) examinations were compared with the CEAP classification, its adjunctive venous clinical severity score, and sensory thresholds [23].
• Cutaneous sensory thresholds from skin overlying masseter and forearm in MPD patients and controls [24].
• Paradoxically, the patient's sensory thresholds negatively correlated with levels of testosterone (p < 0.05) and free testosterone (p < 0.002), and positively with levels of sex hormone-binding globulin (p < 0.05) [25].
• ES2 produced by four times the sensory threshold was lengthened after tizanidine administration [26].
• In contrast to the two cases previously reported by others, in which the preoperative TEPs were normal, the two cases reported herein showed significant changes on the affected side: the sensory thresholds were greater and the peak latencies of P19 and N28 were longer on the affected side than those on the normal side [27].

Analytical, diagnostic and therapeutic context of Sensory Thresholds

• Concentration-effect relations for intravenous lidocaine infusions in human volunteers: effects on acute sensory thresholds and capsaicin-evoked hyperpathia [28].
• Implications: We studied the effects on postsurgical sensory processing of general anesthesia supplemented by drugs affecting opioid or N-methyl-D-aspartate receptors using sensory thresholds [29].
• A controlled study of quantified clinical neurological examination, including psychophysical assessment of sensory thresholds, in patients with rheumatoid arthritis (RA) was carried out [30].

References