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MeSH Review

Sensory Thresholds

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Disease relevance of Sensory Thresholds


Psychiatry related information on Sensory Thresholds


High impact information on Sensory Thresholds

  • The increase in TRVP1 correlated significantly with the decrease in rectal heat (p=0.03) and the distension (p=0.02) sensory thresholds [9].
  • PP responses and visceral sensory thresholds were significantly correlated (r = 0.65, p < 0.002) [10].
  • An increase of 1 mmol/l in mean fasting blood glucose has an equivalent effect on the sensory threshold to an extra 5 years of age [11].
  • In fewer subjects who used capsaicin cream in an open-label study, there was no significant effect on sensory thresholds after up to 32 wk of use [12].
  • It was hypothesized that the removal of this intermittent auditory stimulation, simulating in waking subjects the increased sensory thresholds of REM sleep, would decrease the number of topic shifts in spontaneous thought [13].

Chemical compound and disease context of Sensory Thresholds


Biological context of Sensory Thresholds


Anatomical context of Sensory Thresholds


Gene context of Sensory Thresholds

  • Findings from clinical and duplex ultrasound scan (DU) examinations were compared with the CEAP classification, its adjunctive venous clinical severity score, and sensory thresholds [23].
  • Cutaneous sensory thresholds from skin overlying masseter and forearm in MPD patients and controls [24].
  • Paradoxically, the patient's sensory thresholds negatively correlated with levels of testosterone (p < 0.05) and free testosterone (p < 0.002), and positively with levels of sex hormone-binding globulin (p < 0.05) [25].
  • ES2 produced by four times the sensory threshold was lengthened after tizanidine administration [26].
  • In contrast to the two cases previously reported by others, in which the preoperative TEPs were normal, the two cases reported herein showed significant changes on the affected side: the sensory thresholds were greater and the peak latencies of P19 and N28 were longer on the affected side than those on the normal side [27].

Analytical, diagnostic and therapeutic context of Sensory Thresholds


  1. Dose response, coasting, and differential fiber vulnerability in human toxic neuropathy: a prospective study of pyridoxine neurotoxicity. Berger, A.R., Schaumburg, H.H., Schroeder, C., Apfel, S., Reynolds, R. Neurology (1992) [Pubmed]
  2. Inflammatory pain and hypersensitivity are selectively reversed by epidural bupivacaine and are developmentally regulated. Howard, R.F., Hatch, D.J., Cole, T.J., Fitzgerald, M. Anesthesiology (2001) [Pubmed]
  3. Gabapentin reduces rectal mechanosensitivity and increases rectal compliance in patients with diarrhoea-predominant irritable bowel syndrome. Lee, K.J., Kim, J.H., Cho, S.W. Aliment. Pharmacol. Ther. (2005) [Pubmed]
  4. Sorbitol and myo-inositol levels and morphology of sural nerve in relation to peripheral nerve function and clinical neuropathy in men with diabetic, impaired, and normal glucose tolerance. Sundkvist, G., Dahlin, L.B., Nilsson, H., Eriksson, K.F., Lindgärde, F., Rosén, I., Lattimer, S.A., Sima, A.A., Sullivan, K., Greene, D.A. Diabet. Med. (2000) [Pubmed]
  5. Analgesic effects of dexamethasone in burn injury. Werner, M.U., Lassen, B., Kehlet, H. Regional anesthesia and pain medicine. (2002) [Pubmed]
  6. Effects of diazepam and triazolam on auditory and visual thresholds and reaction times in the baboon. Lukas, S.E., Hienz, R.D., Brady, J.V. Psychopharmacology (Berl.) (1985) [Pubmed]
  7. Effects of diflunisal on cutaneous sensory and pain thresholds. Dragani, L., Giamberardino, M.A., Obletter, G., Vecchiet, L. Clinical therapeutics. (1988) [Pubmed]
  8. Psychophysical profiles differentiate drugs of abuse. Hienz, R.D., Brady, J.V. NIDA Res. Monogr. (1981) [Pubmed]
  9. Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency. Chan, C.L., Facer, P., Davis, J.B., Smith, G.D., Egerton, J., Bountra, C., Williams, N.S., Anand, P. Lancet (2003) [Pubmed]
  10. Altered vagal and intestinal mechanosensory function in chronic unexplained dyspepsia. Holtmann, G., Goebell, H., Jockenhoevel, F., Talley, N.J. Gut (1998) [Pubmed]
  11. Hyperglycaemia is one correlate of deterioration in vibration sense during the 5 years after diagnosis of type 2 (non-insulin-dependent) diabetes. Hillson, R.M., Hockaday, T.D., Newton, D.J. Diabetologia (1984) [Pubmed]
  12. Topical capsaicin in painful diabetic neuropathy. Effect on sensory function. Tandan, R., Lewis, G.A., Badger, G.B., Fries, T.J. Diabetes Care (1992) [Pubmed]
  13. Sleeping and waking thought: effects of external stimulation. Wollman, M.C., Antrobus, J.S. Sleep. (1986) [Pubmed]
  14. Effects of local anesthetics on tactile sensitivity thresholds for cutaneous and mucous membranes. Weinstein, S. J. Invest. Dermatol. (1977) [Pubmed]
  15. Concentration-effect relationship of intravenous lidocaine on the allodynia of complex regional pain syndrome types I and II. Wallace, M.S., Ridgeway, B.M., Leung, A.Y., Gerayli, A., Yaksh, T.L. Anesthesiology (2000) [Pubmed]
  16. Effect of propofol on spinal dorsal horn neurons. Comparison with lack of ketamine effects. Uchida, H., Kishikawa, K., Collins, J.G. Anesthesiology (1995) [Pubmed]
  17. Functional chest pain of esophageal origin: hyperalgesia or motor dysfunction. Rao, S.S., Hayek, B., Summers, R.W. Am. J. Gastroenterol. (2001) [Pubmed]
  18. Sensory thresholds and the antinociceptive effects of GABA receptor agonists in mice lacking the beta3 subunit of the GABA(A) receptor. Ugarte, S.D., Homanics, G.E., Firestone, L.L., Hammond, D.L. Neuroscience (2000) [Pubmed]
  19. The effects of fluoxetine on several neurophysiological variables in patients with premature ejaculation. Yilmaz, U., Tatlişen, A., Turan, H., Arman, F., Ekmekçioğlu, O. J. Urol. (1999) [Pubmed]
  20. Postoperative sensitization and pain after cesarean delivery and the effects of single im doses of tramadol and diclofenac alone and in combination. Wilder-Smith, C.H., Hill, L., Dyer, R.A., Torr, G., Coetzee, E. Anesth. Analg. (2003) [Pubmed]
  21. Evidence of gender differences in esophageal pain threshold. Nguyen, P., Lee, S.D., Castell, D.O. Am. J. Gastroenterol. (1995) [Pubmed]
  22. Vibrotactile threshold measurement for detecting neurotoxicity: reliability and determination of age- and height-standardized normative values. Gerr, F., Hershman, D., Letz, R. Arch. Environ. Health (1990) [Pubmed]
  23. Does severe venous insufficiency have a different etiology in the morbidly obese? Is it venous? Padberg, F., Cerveira, J.J., Lal, B.K., Pappas, P.J., Varma, S., Hobson, R.W. J. Vasc. Surg. (2003) [Pubmed]
  24. Cutaneous sensory thresholds from skin overlying masseter and forearm in MPD patients and controls. Davidson, R.M., Gale, E.N. J. Dent. Res. (1983) [Pubmed]
  25. Do male sex hormones protect from irritable bowel syndrome? Houghton, L.A., Jackson, N.A., Whorwell, P.J., Morris, J. Am. J. Gastroenterol. (2000) [Pubmed]
  26. Effects of tizanidine administration on exteroceptive suppression of the temporalis muscle in patients with chronic tension-type headache. Nakashima, K., Tumura, R., Wang, Y., Shimoda, M., Sakuma, K., Takahashi, K. Headache. (1994) [Pubmed]
  27. Trigeminal sensory evoked potentials in patients with trigeminal neurinoma: report of two cases. Takayasu, M., Shibuya, M., Suzuki, Y., Harada, T., Kanamori, M., Kageyama, N. Neurosurgery (1987) [Pubmed]
  28. Concentration-effect relations for intravenous lidocaine infusions in human volunteers: effects on acute sensory thresholds and capsaicin-evoked hyperpathia. Wallace, M.S., Laitin, S., Licht, D., Yaksh, T.L. Anesthesiology (1997) [Pubmed]
  29. Sensory changes and pain after abdominal hysterectomy: a comparison of anesthetic supplementation with fentanyl versus magnesium or ketamine. Wilder-Smith, O.H., Arendt-Nielsen, L., Gäumann, D., Tassonyi, E., Rifat, K.R. Anesth. Analg. (1998) [Pubmed]
  30. Quantified neurological examination with emphasis on motor and sensory functions in patients with rheumatoid arthritis and controls. Bekkelund, S.I., Mellgren, S.I., Prøven, A., Husby, G. Br. J. Rheumatol. (1996) [Pubmed]
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