Detailed genetic mapping of the A-raf proto-oncogene on the mouse X chromosome.
The transcribed murine A-raf proto-oncogene has been localized to the proximal region of the mouse X chromosome, within the context of four other active genes in this region which together constitute a conserved linkage group between mouse and man. This localization has been accomplished using species-specific restriction fragment length variation and DNAs from a previously defined informative subset of progeny representative of a set of 100 progeny from an interspecific backcross between inbred C57BL/6JRos and wild-derived Mus spretus. This new data regionally orders the mouse A-raf locus relative to the 24 X-linked markers previously examined in this backcross. We find that A-raf co-localizes with two other active genes, tissue inhibitor of metalloproteinases ( Timp) and synapsin ( Syn-1), 4.0 +/- 2.0 cM distal to the Otc gene at the proximal end of the mouse X chromosome, for a partial gene order in this region of: centromere-Cybb-Otc- Timp/A-raf/ Syn-1-Xlr-1-Hprt.[1]References
- Detailed genetic mapping of the A-raf proto-oncogene on the mouse X chromosome. Grant, S.G., Chapman, V.M. Oncogene (1991) [Pubmed]
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