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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Langerhans cell histiocytosis: fascinating dynamics of the dendritic cell-macrophage lineage.

In its rare occurrence, Langerhans cell histiocytosis (LCH) is a dangerous but intriguing deviation of mononuclear phagocytes, especially dendritic cells (DCs). Clinically, the disease ranges from self-resolving or well manageable to severe and even fatal. LCH lesions in skin, bone, and other sites contain high numbers of cells with phenotypic features resembling LCs admixed with macrophages, T cells, eosinophils, and multinucleated giant cells. Here we review current progress in the LCH field based on two central questions: (i) are LCH cells intrinsically aberrant, and (ii) how does the lesion drive pathogenesis? We argue that LCH cells may originate from different sources, including epidermal LCs, tissue Langerin(+) DCs, or mononuclear phagocyte precursors. Current and prospective in vitro and in vivo models are discussed. Finally, we discuss recent insights into plasticity of T-helper cell subsets in light of the lesion microenvironment. LCH continues to provide urgent clinical questions thereby inspiring innovative DC lineage research.[1]

References

  1. Langerhans cell histiocytosis: fascinating dynamics of the dendritic cell-macrophage lineage. Egeler, R.M., van Halteren, A.G., Hogendoorn, P.C., Laman, J.D., Leenen, P.J. Immunol. Rev. (2010) [Pubmed]
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