Disease relevance of Histiocytosis, Langerhans-Cell

• Canine cutaneous histiocytoma is an epidermotropic Langerhans cell histiocytosis that expresses CD1 and specific beta 2-integrin molecules [1].
• Hemophagocytic lymphohistiocytosis (HLH) and Langerhans cell histiocytosis (LCH) are members of a group of rare heterogenous disorders, the histiocytoses, characterized by uncontrolled accumulation of pleomorphic infiltrates of leukocytes [2].
• Hypercalcemia in Langerhans' cell granulomatosis with elevated 1,25 dihydroxyvitamin D (calcitriol) level [3].
• We retrospectively studied the outcome of percutaneous needle biopsy and intralesional injection of a corticosteroid (methylprednisolone) in thirty-nine patients who had localized Langerhans-cell histiocytosis (eosinophilic granuloma of bone) [4].
• METHODS: The hypothalamic-neurohypophyseal axis was studied by sagittal and coronal 1.5 T1-weighted MR imaging in 14 children with Langerhans cell histiocytosis (five with diabetes insipidus) and in 28 low-stature controls, ages 6-14 years [5].

High impact information on Histiocytosis, Langerhans-Cell

• Aberrant chemokine receptor expression and chemokine production by Langerhans cells underlies the pathogenesis of Langerhans cell histiocytosis [6].
• We used such an assay at the human androgen-receptor gene locus in three female patients with histologically proven Langerhans cell histiocytosis [7].
• CD1 antibody immunolocalisation in Langerhans' cell histiocytosis [8].
• 2-Chlorodeoxyadenosine-induced complete remissions in Langerhans-cell histiocytosis [9].
• Langerhans cells and the cells of Langerhans cell histiocytosis do not express DC-SIGN [10].

Chemical compound and disease context of Histiocytosis, Langerhans-Cell

• Cyclosporine therapy for advanced Langerhans cell histiocytosis [11].
• CONCLUSION: 111In-pentetreotide imaging may be useful in Langerhans' cell histiocytosis [12].
• 2'-Deoxycoformycin as treatment in refractory Langerhans cell histiocytosis [13].
• In 16 children with multisystem Langerhans cell histiocytosis (mean age 22 months, range 5 to 36 months) severe symptomatic skin involvement was treated with topical nitrogen mustard (mechlorethamine hydrochloride) [14].
• The aim of this study was to assess the efficacy and adverse effects of 2-chlorodeoxyadenosine (2-CdA) and cytosine arabinoside (Ara-C) in children with refractory Langerhans cell histiocytosis (LCH) and haematopoietic dysfunction [15].

Biological context of Histiocytosis, Langerhans-Cell

• Antigenic phenotype of Langerhans cell histiocytosis: an immunohistochemical study demonstrating the value of LN-2, LN-3, and vimentin [16].
• Ultrastructurally, no Birbeck granules were observed, and immunochemistry did not reveal any S-100 protein or CD1a antigen in any of the lesional cells, excluding Langerhans cell histiocytosis [17].

Anatomical context of Histiocytosis, Langerhans-Cell

• We postulate that expression of CCR3 may underlie situations where both DCs and eosinophils accumulate in vivo, such as the lesions of patients with Langerhans cell granulomatosis [18].
• Clinical and histopathological similarities with other forms of disseminated Langerhans' cell histiocytosis are noted, particularly reaction of infiltrating histiocytes for S100 and HLA-DR [19].
• Langerhans cell histiocytosis involving the corpus callosum and cerebellum: gadolinium-enhanced MRI [20].
• We report a 6-year-old girl with Langerhans cell histiocytosis (LCH) of the sternum successfully managed with intralesional methylprednisolone [21].
• A case in which there was thallium-201 (201Tl) uptake in Langerhans cell histiocytosis (LCH) of the left femoral diaphysis is presented [22].

Gene context of Histiocytosis, Langerhans-Cell

• Immunohistochemical detection of the apoptosis-related proteins FADD, FLICE, and FLIP in Langerhans cell histiocytosis [23].
• Abundant expression of CD40 and CD40-ligand (CD154) in paediatric Langerhans cell histiocytosis lesions [24].
• Langerhans cell histiocytosis in children: does soluble interleukin-2-receptor correlate with both disease extent and activity [25]?
• Further studies are necessary to confirm the diagnostic value of this technique and clarify the biologic significance of the expression of somatostatin receptors in Langerhans cell histiocytosis [26].
• The role of vascular endothelial growth factor in Langerhans cell histiocytosis [27].

Analytical, diagnostic and therapeutic context of Histiocytosis, Langerhans-Cell

• 111In-pentetreotide scintigraphy in patients with Langerhans' cell histiocytosis [12].
• We describe a 4-year-old child whose disseminated, refractory Langerhans' cell histiocytosis was not controlled by front-line monotherapy with etoposide, nor by rescue treatment with combined chemotherapy (vinblastine and etoposide) and immunotherapy (steroids and cyclosporine) [28].
• We were recently able to observe, by electron microscopy, Charcot-Leyden crystals in the cutaneous lesions of histiocytosis X (Letterer-Siwe disease) that had been treated by local applications of mechlorethamine [29].
• METHODS AND RESULTS: The expression of CD101 was studied by immunohistochemical technique in 11 cases of Langerhans cell histiocytosis on frozen sections [30].
• Hematopoietic stem cell transplantation in patients with severe Langerhans cell histiocytosis and hematological dysfunction: experience of the French Langerhans Cell Study Group [31].

References