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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Elongation factor Tu is methylated in response to nutrient deprivation in Escherichia coli.

It has been shown previously that starvation of a mid-logarithmic-phase culture of Escherichia coli B/r for an essential nutrient results in the methylation of a membrane-associated protein (P-43) (C. C. Young and R. W. Bernlohr, J. Bacteriol. 172:5147-5153, 1990). In this communication, the purification of P-43 and sequence analysis of cyanogen bromide-generated peptide fragments identified P-43 as elongation factor Tu (EF-Tu). This was confirmed by the ability of anti-EF-Tu antibody to precipitate P-43. We propose that the nutrient-dependent methylation of EF-Tu may be involved in the regulation of growth, possibly as a principal component of an unidentified signal transduction pathway in bacteria.[1]


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