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Gene Review

tuf  -  elongation factor Tu

Escherichia coli CFT073

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Disease relevance of tuf


High impact information on tuf

  • The mutations had no effect on EF-Tu-dependent delivery of aminoacyl-tRNA to the ribosome [3].
  • An important feature of the nucleotide exchange is the structural rearrangement of EF-Tu in the EF-Tu.EF-Ts complex caused by insertion of Phe-81 of EF-Ts between His-84 and His-118 of EF-Tu [3].
  • The importance of P-loop and domain movements in EF-Tu for guanine nucleotide exchange [3].
  • These inclusion bodies additionally contain significant amounts of the heat-shock chaperone DnaK, and putative DnaK substrates such as the elongation factor Tu (ET-Tu) and the metabolic enzymes dihydrolipoamide dehydrogenase (LpdA), tryptophanase (TnaA), and d-tagatose-1,6-bisphosphate aldolase (GatY) [4].
  • Current research and developmental efforts are aimed at the design of a new class of antibacterial drugs, acting by destabilization of the EF-Tu-containing bacterial cytoskeleton, and of an innovative mode of inducible lysis of recombinant bacteria by controlled destabilization of the EF-Tu-containing cytoskeleton [1].


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