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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Disparate effects of feeding on core body and adipose tissue temperatures in animals selectively bred for Nervous or Calm temperament.

In addition to homeostatic regulation of body mass, nonhomeostatic factors impact on energy balance. Herein we describe effects of temperament on adipose and core body temperatures in sheep. Animals were genetically selected for Nervous or Calm traits. We characterized the effects of 1) high- and low-energy intake and maintenance feeding, 2) meal anticipation, and 3) adrenocorticotropin challenge on core body and adipose temperatures. Temperature measurements (5 min) were made using a thermistor inserted into the carotid artery (core body) and a probe in the retroperitoneal fat. An imposed feeding window was used to establish postprandial elevations in temperature. Fat tissue was taken from retroperitoneal and subcutaneous regions for real-time PCR analyses. We demonstrate that innate differences in temperament impact on adipose and core body temperatures in response to various dietary and evocative stimuli. In response to homeostatic cues (low-energy intake and maintenance feeding) core body temperature tended to be higher in Calm compared with Nervous animals. In contrast, in response to nonhomeostatic cues, Nervous animals had higher anticipatory thermogenic responses than Calm animals. Expression of uncoupling protein (UCP)-1 and -2 mRNA were higher in retroperitoneal tissue than in subcutaneous tissue, but UCP3 and leptin mRNA levels were similar at both sites; expression of these genes was similar in Nervous and Calm animals. There were no differences in stress responsiveness. We conclude that temperament differentially influences adipose thermogenesis and the regulation of core body temperature in responses to both homeostatic and nonhomeostatic stimuli.[1]


  1. Disparate effects of feeding on core body and adipose tissue temperatures in animals selectively bred for Nervous or Calm temperament. Henry, B.A., Blache, D., Rao, A., Clarke, I.J., Maloney, S.K. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2010) [Pubmed]
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