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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Identification of an amino acid sequence from the laminin A chain that stimulates metastasis and collagenase IV production.

Tumor cells attach, degrade, and migrate through basement membranes as they metastasize. Laminin, a major glycoprotein of basement membranes, promotes the metastatic activity of tumor cells by stimulating the attachment and migration of the cells and their secretion of collagenase IV. We have identified a synthetic peptide of 19 amino acids (Cys-Ser-Arg-Ala-Arg-Lys-Gln-Ala-Ala-Ser-Ile-Lys-Val-Ala-Val-Ser-Ala-Asp -Arg) from the sequence of the A chain of laminin that increases experimental metastases of the lungs by murine melanoma cells. The peptide is active when injected either intravenously or intraperitoneally. The peptide increased collagenase IV activity, a key enzyme in the breakdown of basement membranes, to the same extent as laminin. This peptide represents an active site on laminin for promotion of the metastatic phenotype and generates a probe for studying the regulation of malignant activities.[1]

References

  1. Identification of an amino acid sequence from the laminin A chain that stimulates metastasis and collagenase IV production. Kanemoto, T., Reich, R., Royce, L., Greatorex, D., Adler, S.H., Shiraishi, N., Martin, G.R., Yamada, Y., Kleinman, H.K. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
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