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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Toxic dermatitis induced by 10-ethyl-10-deaza-aminopterin (10-EdAM), a novel antifolate.

A new methotrexate analog, 10-ethyl-10-deaza-aminopterin (10-EdAM), was found to induce a particular form of skin toxicity different than the skin rash reported to result from methotrexate. At histologic examination, it was found to be a toxic dermatitis that clinically most often first appears on the lower legs but can occur anywhere in the body, especially if treatment is continued. Nine cases are reported. A specific risk factor could not yet be identified. Discontinuation of 10-EdAM administration leads to complete healing; concomitant corticosteroid treatment also induces healing.[1]

References

  1. Toxic dermatitis induced by 10-ethyl-10-deaza-aminopterin (10-EdAM), a novel antifolate. Verweij, J., Schornagel, J., de Mulder, P., Henzen-Logmans, S., Cognetti, F., Clavel, M., Vermorken, J. Cancer (1990) [Pubmed]
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