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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Expression and chromosomal localization of a lymphocyte K+ channel gene.

We recently isolated a family of three closely related mouse K+ channel genes ( MK1, MK2, and MK3) with coding regions contained in single uninterrupted exons. Here we have used patch-clamp recordings from Xenopus oocytes injected with mRNA to show that MK3 encodes a channel with biophysical and pharmacological properties indistinguishable from those of voltage-gated type n K+ channels in T cells. In addition, we used the polymerase chain reaction to demonstrate the presence of MK3 mRNA in T cells. These data suggest that MK3 may encode the T-cell voltage-gated type n K+ channel. We also show that MK3 and MK2 are localized on human chromosomes 13 and 12, respectively.[1]


  1. Expression and chromosomal localization of a lymphocyte K+ channel gene. Grissmer, S., Dethlefs, B., Wasmuth, J.J., Goldin, A.L., Gutman, G.A., Cahalan, M.D., Chandy, K.G. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
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