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Gene Review

KCNA2  -  potassium channel, voltage gated shaker...

Homo sapiens

Synonyms: HBK5, HK4, HUKIV, KV1.2, Kv1.2, ...
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Disease relevance of KCNA2


High impact information on KCNA2


Biological context of KCNA2

  • We recently isolated a family of three closely related mouse K+ channel genes (MK1, MK2, and MK3) with coding regions contained in single uninterrupted exons [2].
  • Gene expression studies of Shaker KV1 transcripts have shown that of the dominant species present in arterial SMCs, KV1.2 expression is higher, whereas KV1.5 is the same in SMCs from hypertensive compared to normal animals [6].

Anatomical context of KCNA2


Associations of KCNA2 with chemical compounds

  • 4-Aminopyridine (4-AP), non selective blocker of voltage gated K+ (KV) channels, and margatoxin that inhibits KV1.2, KV1.3, and KV1.6 channels abolished relaxation of HIMA rings induced by resveratrol [8].
  • We found that Kv1.2 is regulated by two distinct cAMP pathways, one PKA-dependent and the other PKA-independent [9].

Analytical, diagnostic and therapeutic context of KCNA2


  1. Repression of enhancer activity by the adenovirus E1A tumor protein(s) is mediated through a novel HeLa cell nuclear factor. Reifel-Miller, A.E., Berg, D.T., Grinnell, B.W. J. Biol. Chem. (1991) [Pubmed]
  2. Expression and chromosomal localization of a lymphocyte K+ channel gene. Grissmer, S., Dethlefs, B., Wasmuth, J.J., Goldin, A.L., Gutman, G.A., Cahalan, M.D., Chandy, K.G. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  3. Voltage-gated K+ channels in rat small cerebral arteries: molecular identity of the functional channels. Albarwani, S., Nemetz, L.T., Madden, J.A., Tobin, A.A., England, S.K., Pratt, P.F., Rusch, N.J. J. Physiol. (Lond.) (2003) [Pubmed]
  4. CD23-mediated transport of IgE/immune complexes across human intestinal epithelium: role of p38 MAPK. Tu, Y., Perdue, M.H. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  5. Dendrotoxin poisoning in a neurobiochemist. Munday, S.W., Williams, S.R., Clark, R.F. J. Toxicol. Clin. Toxicol. (2003) [Pubmed]
  6. Changes in the expression and function of arterial potassium channels during hypertension. Cox, R.H. Vascul. Pharmacol. (2002) [Pubmed]
  7. Does the hemoglobin concentration in fetal blood interfere with the accuracy of fetal reflection pulse oximetry? Arikan, G.M., Haeusler, M.C., Haas, J., Scholz, H. Fetal. Diagn. Ther. (1998) [Pubmed]
  8. The mechanism of endothelium-independent relaxation induced by the wine polyphenol resveratrol in human internal mammary artery. Novakovic, A., Gojkovic-Bukarica, L., Peric, M., Nezic, D., Djukanovic, B., Markovic-Lipkovski, J., Heinle, H. J. Pharmacol. Sci. (2006) [Pubmed]
  9. Homeostatic regulation of Kv1.2 potassium channel trafficking by cyclic AMP. Connors, E.C., Ballif, B.A., Morielli, A.D. J. Biol. Chem. (2008) [Pubmed]
  10. Ventilator modifications for intermittent mandatory ventilation. Krauel, J., Poderós, B., Baráibar, R., Molina, V., García-Tornel, S. Crit. Care Med. (1979) [Pubmed]
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