Disease relevance of KCNA2

• The enhancer used in this study, from the human BK virus P2, functions efficiently in cis to activate expression from the adenovirus major late promoter in the human kidney cell line, 293, and in a monkey kidney cell line, MK2 [1].

High impact information on KCNA2

• We also show that MK3 and MK2 are localized on human chromosomes 13 and 12, respectively [2].
• The expression of these proteins in VSMCs was confirmed by immunocytochemistry and co-immunoprecipitation of KV1.2 and 1.5 from VSMC membranes suggested KV1.2/1.5 channel assembly [3].
• The findings of this study suggest that KV1.2/1.5 heterotetramers are preferentially expressed in rat cerebral VSMCs, and that these channels contribute to the resting membrane potential and diameter of rat small cerebral arteries [3].
• The inhibitors exerted effects in the pathway post the p38 MAPK; SB203580 significantly inhibited the phosphorylation of MK-2 [4].
• BACKGROUND: Dendrotoxin is a highly potent blocker of KV1.1, KV1.2, and KV1.6 potassium channels that is derived from the venom of the green mamba (Dendroaspis angusticeps) [5].

Biological context of KCNA2

• We recently isolated a family of three closely related mouse K+ channel genes (MK1, MK2, and MK3) with coding regions contained in single uninterrupted exons [2].
• Gene expression studies of Shaker KV1 transcripts have shown that of the dominant species present in arterial SMCs, KV1.2 expression is higher, whereas KV1.5 is the same in SMCs from hypertensive compared to normal animals [6].

Anatomical context of KCNA2

• METHODS: 179 fetuses were monitored by a reflection pulse oximetry system (RPOX MK2) [7].

Associations of KCNA2 with chemical compounds

• 4-Aminopyridine (4-AP), non selective blocker of voltage gated K+ (KV) channels, and margatoxin that inhibits KV1.2, KV1.3, and KV1.6 channels abolished relaxation of HIMA rings induced by resveratrol [8].
• We found that Kv1.2 is regulated by two distinct cAMP pathways, one PKA-dependent and the other PKA-independent [9].

Analytical, diagnostic and therapeutic context of KCNA2

• However, only the KV1.2 and 1.5 proteins were detected by Western blot [3].
• A Loosko MK2 ventilator has been modified to provide IMV in newborns [10].

References