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Gene Review

KCNA3  -  potassium channel, voltage gated shaker...

Homo sapiens

Synonyms: HGK5, HLK3, HPCN3, HUKIII, KV1.3, ...
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Disease relevance of KCNA3

  • It codes for MK3 protein that similarly as K5 protein of Kaposi's sarcoma-associated herpesvirus are members of a family of structurally related viral immune evasion molecules possessing RING-CH finger domain with ubiquitin ligase activity [1].
  • Similar staining patterns within epidermis were seen with HLK3 (intercellular) and HLK7 (perinuclear) in psoriasis, SCC, and BCC [2].
  • The immunofluorescent staining patterns of three differentiation-specific monoclonals (HLK3, HLK7, HLK20) that display different immunofluorescent (IF) reactivity in normal and psoriatic epidermis, were examined in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), as well as other human normal epithelial and nonepithelial tissues [2].
  • SLE, but not rheumatoid arthritis, T cells show faster kinetics with maximum Kv1.3 recruitment at 1 min and movement out of the IS by 15 min after activation [3].

High impact information on KCNA3


Biological context of KCNA3

  • Confirmation of the assignment of the gene encoding Kv1.3, a voltage-gated potassium channel (KCNA3) to the proximal short arm of human chromosome 1 [6].
  • HLK3 current is very sensitive to the scorpion toxin charybdotoxin (IC50 = 0.8 nM) [7].
  • Low stringency screening of a Jurkat cDNA library with a rat brain K+ channel (RCK1) probe has resulted in the isolation of HLK3, a voltage-gated K+ channel [7].
  • We report the characterization of a human genomic DNA clone, HGK5, encoding a 523-amino-acid potassium channel protein encoded by an open reading frame on a single exon [8].
  • That region of chromosome 1 contains another K channel gene, KCNA3 [9].

Anatomical context of KCNA3

  • It is concluded that the HLK3 channel is not an important component of the T cell mitogenic response [7].
  • RNA transcribed in vitro from HGK5 genomic DNA directs expression of functional voltage-dependent potassium currents in Xenopus oocytes [8].
  • CONTEXT: The voltage-gated potassium channel Kv1.3 (KCNA3) is expressed in a variety of tissues including liver and skeletal muscle [10].
  • These data suggest that the second messengers generated by phospholipase C activation may be important modulators of HLK3 K+ channels in the immune and the central nervous systems [11].
  • Antibodies targeted to KValpha1 subunits revealed KV1.3 and KV1.6 expression in whole bladder tissue samples and specifically in detrusor smooth muscle cells [12].

Associations of KCNA3 with chemical compounds


Analytical, diagnostic and therapeutic context of KCNA3


  1. Murine gammaherpesvirus (MHV) MK3 gene sequence diversity among 72, 4556, and 68 strains. Valovicová, M., Rezuchorá, I., Macáková, K., Petrová, P., Matis, J., Kúdelová, M. Virus Genes (2006) [Pubmed]
  2. Specificity of human keratinocyte X HeLa cell hybrid murine monoclonal antibodies. Kwiatkowska, B., McCullough, J.L., Weinstein, G.D., Stanbridge, E.J. International journal of dermatology. (1991) [Pubmed]
  3. Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosus. Nicolaou, S.A., Szigligeti, P., Neumeier, L., Lee, S.M., Duncan, H.J., Kant, S.K., Mongey, A.B., Filipovich, A.H., Conforti, L. J. Immunol. (2007) [Pubmed]
  4. MHC class I ubiquitination by a viral PHD/LAP finger protein. Boname, J.M., Stevenson, P.G. Immunity (2001) [Pubmed]
  5. Expression and chromosomal localization of a lymphocyte K+ channel gene. Grissmer, S., Dethlefs, B., Wasmuth, J.J., Goldin, A.L., Gutman, G.A., Cahalan, M.D., Chandy, K.G. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  6. Confirmation of the assignment of the gene encoding Kv1.3, a voltage-gated potassium channel (KCNA3) to the proximal short arm of human chromosome 1. Folander, K., Douglass, J., Swanson, R. Genomics (1994) [Pubmed]
  7. Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes. Attali, B., Romey, G., Honoré, E., Schmid-Alliana, A., Mattéi, M.G., Lesage, F., Ricard, P., Barhanin, J., Lazdunski, M. J. Biol. Chem. (1992) [Pubmed]
  8. Characterization and functional expression of genomic DNA encoding the human lymphocyte type n potassium channel. Cai, Y.C., Osborne, P.B., North, R.A., Dooley, D.C., Douglass, J. DNA Cell Biol. (1992) [Pubmed]
  9. Genomic localization of the human gene for KCNA10, a cGMP-activated K channel. Orias, M., Bray-Ward, P., Curran, M.E., Keating, M.T., Desir, G.V. Genomics (1997) [Pubmed]
  10. A new variant in the human Kv1.3 gene is associated with low insulin sensitivity and impaired glucose tolerance. Tschritter, O., Machicao, F., Stefan, N., Schäfer, S., Weigert, C., Staiger, H., Spieth, C., Häring, H.U., Fritsche, A. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  11. Regulation of a major cloned voltage-gated K+ channel from human T lymphocytes. Attali, B., Honoré, E., Lesage, F., Lazdunski, M., Barhanin, J. FEBS Lett. (1992) [Pubmed]
  12. Potassium channel KV alpha1 subunit expression and function in human detrusor muscle. Davies, A.M., Batchelor, T.J., Eardley, I., Beech, D.J. J. Urol. (2002) [Pubmed]
  13. The mechanism of endothelium-independent relaxation induced by the wine polyphenol resveratrol in human internal mammary artery. Novakovic, A., Gojkovic-Bukarica, L., Peric, M., Nezic, D., Djukanovic, B., Markovic-Lipkovski, J., Heinle, H. J. Pharmacol. Sci. (2006) [Pubmed]
  14. Vitamin K2 and its derivatives induce apoptosis in leukemia cells and enhance the effect of all-trans retinoic acid. Yaguchi, M., Miyazawa, K., Katagiri, T., Nishimaki, J., Kizaki, M., Tohyama, K., Toyama, K. Leukemia (1997) [Pubmed]
  15. Nebulizer calibration using lithium chloride: an accurate, reproducible and user-friendly method. Ward, R.J., Reid, D.W., Leonard, R.F., Johns, D.P., Walters, E.H. Eur. Respir. J. (1998) [Pubmed]
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