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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Nonsteroidal anti-inflammatory drugs and coma: a case report of fenoprofen overdose.

We present the case of a 17-year-old girl who ingested 24 to 36 g fenoprofen as a suicidal gesture. She presented with coma, hypotension, metabolic acidosis, and respiratory depression within four hours of ingestion. The most common adverse effects of the nonsteroidal anti-inflammatory drugs occur in both therapeutic and toxic doses and include gastrointestinal upset, blood dyscrasias, and analgesic nephropathy. The propionic acid derivatives of nonsteroidal anti-inflammatory drugs, including fenoprofen and ibuprofen, are rarely associated with severe toxic effects. This is the first report of pure fenoprofen overdose presenting as coma and metabolic acidosis.[1]


  1. Nonsteroidal anti-inflammatory drugs and coma: a case report of fenoprofen overdose. Kolodzik, J.M., Eilers, M.A., Angelos, M.G. Annals of emergency medicine. (1990) [Pubmed]
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