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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Müllerian inhibiting substance as oocyte meiosis inhibitor.

Müllerian inhibiting substance (MIS) inhibited the resumption of meiosis in both denuded and cumulus cell-enclosed rat oocytes in vitro. Spontaneous germinal vesicle breakdown was prevented in both types of oocytes treated by a purified MIS preparation at protein concentrations of 15 micrograms to 150 pg/ml. The inhibiting effect of MIS on the resumption of meiosis was dose dependent, reversible and cyclic AMP independent. Neither follicular-stimulating hormone, luteinizing hormone, progesterone, estradiol, nor testosterone acted significantly to influence MIS-mediated inhibition of rat oocyte maturation. In contrast, MIS had no influence on meiosis in the mouse, where other protein has been reported to inhibit the cumulus cell-enclosed oocyte in a cyclic AMP-dependent fashion. Thus MIS may be yet another inhibitor of oocyte meiosis, acting in the rat by a mechanism different from those inhibitors known, in the mouse ovary, to exert their effect in a cyclic AMP-dependent manner.[1]


  1. Müllerian inhibiting substance as oocyte meiosis inhibitor. Takahashi, M., Koide, S.S., Donahoe, P.K. Mol. Cell. Endocrinol. (1986) [Pubmed]
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