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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Action of antidepressants on the septal nuclei of the rat.

Studies on neuronal firing have shown a decrease in frequency of firing in structures not directly related to emotional processes. However, studies of the hippocampus have shown increases in firing rate. Other limbic structures not yet explored in regard to the action of antidepressants include the septal nuclei. The present work describes a common effect of various therapeutic antidepressant models. Extracellular unit recordings were obtained from the septal nuclei of rats exposed to different acute treatments: clomipramine, isocarboxazid, trazodone, sleep deprivation, and electroshock. Frequencies and firing intervals were analyzed. After treatment, an increase in firing frequency in cells of the dorsolateral septal nucleus was found. This supports the hypothesis that brain structures related to the phenomenon of self-stimulation participate in the mechanism of antidepressant treatments.[1]


  1. Action of antidepressants on the septal nuclei of the rat. Contreras, C.M., Alcalá-Herrera, V., Marván, M.L. Physiol. Behav. (1989) [Pubmed]
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