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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Hartmann, J. et al.

Blood pressure reduction in hypertensive-diabetic rats by the somatostatin analog MK-678.

A hypotensive effect of an orally-administered cyclopeptide somatostatin analog, MK-678, has been demonstrated in a hypertensive diabetic rat model. Sustained blood pressure reduction failed to occur when the drug was administered to the spontaneously hypertensive rat. The mechanism of hypotension appears independent of effects on a variety of hormones including insulin, glucagon, growth hormone, and components of the renin-angiotensin system including renin activity, plasma angiotensin converting enzyme, and aldosterone.[1]

References

Blood pressure reduction in hypertensive-diabetic rats by the somatostatin analog MK-678. Hartmann, J., Szemplinski, M., Chen, S.L., Slater, E. Life Sci. (1989) [Pubmed]

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