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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Amphetamine stereotypy in cats and neurotransmitter interactions in the caudate nucleus. III. Effects of intracaudate injections of quipazine, cyproheptadine and electrical stimulation of the raphe dorsal nucleus.

The effect of quipazine and cyproheptadine injected into the rostrodorsal part of the caudate nucleus on spontaneous and amphetamine-induced stereotyped behavior was investigated in free moving cats. Quipazine increased focused and even more locomotor (non-focused) stereotyped behavior, augmented the contralateral head movements and decreased the ipsilateral ones. Cyproheptadine decreased focused stereotypy but increased locomotion and the ipsilateral head movements. These results suggest that the serotonin (S-HT) innervation in the region investigated (rostrodorsal caudate nucleus) has an action synergic with that of dopamine released by amphetamine, i. e. if the inhibitory DA receptors prevail over the excitatory ones in this part of the caudate nucleus, the 5-HT receptors are probably also inhibitory. However, electrical 10-Hz stimulation of raphe dorsal nucleus (RD) induced a short-term decrease in all stereotyped movements. This findings suggest that the 5-HT innervation of the caudate nucleus has a much more complex character and that the influences from RD could be different from those of treatments which stimulate the 5-HT receptors (at least in the rostrodorsal part of the caudate nucleus).[1]


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