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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Methotrexate-associated, early-onset pancytopenia in rheumatoid arthritis.

A patient with rheumatoid arthritis presented with pancytopenia 3 weeks after initiation of low-dose methotrexate administered orally. She had minimal renal insufficiency and hypoalbuminemia prior to initiation of methotrexate therapy, and had received a nonsteroidal anti-inflammatory drug concurrently. Bone marrow recovery occurred within 3 weeks. Patients receiving low-dose methotrexate therapy for rheumatoid arthritis require early monitoring for bone marrow injury, especially those who have risk factors for possible methotrexate toxicity.[1]

References

  1. Methotrexate-associated, early-onset pancytopenia in rheumatoid arthritis. Doolittle, G.C., Simpson, K.M., Lindsley, H.B. Arch. Intern. Med. (1989) [Pubmed]
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