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Disease relevance of Hypoalbuminemia


Psychiatry related information on Hypoalbuminemia


High impact information on Hypoalbuminemia

  • We have recently identified a unique group of patients whose clinical presentations are characterized by autosomal recessive inheritance, early age of onset, FRDA-like clinical presentations and hypoalbuminemia [7].
  • The hypoalbuminemia in tumor-bearing animals could not be prevented by daily injections of a prostaglandin synthesis inhibitor (indomethacin, 1 microgram/g body wt), but the hepatic acute phase protein serum amyloid P decreased from 157 +/- 12 to 103 +/- 9 micrograms/mL in indomethacin-treated tumor-bearing mice (P less than 0.01) [8].
  • In this study, the alpha 1-antitrypsin concentration in stool and the plasma clearance of alpha 1-antitrypsin in normal subjects and in a consecutive series of patients with chronic diarrhea, malabsorption, or unexplained hypoalbuminemia was determined [9].
  • This effect was, however, associated with a decreased release of arachidonic acid in the presence of hypoalbuminemia, such that the overall conversion of released 14C-arachidonic acid to platelet thromboxane B2 was similar in the presence of physiologic albumin concentration (3.5 g/dl) or at decreased albumin concentrations of 0.7 and 0.0 g/dl [10].
  • Hypoalbuminemia enhanced the conversion of released 14C-arachidonic acid from prelabeled platelet phospholipids to the metabolites of the platelet cyclooxygenase and lipoxygenase pathways [10].

Chemical compound and disease context of Hypoalbuminemia

  • In patients with abnormal total bilirubin (i.e., greater than 1.5 mg/dl) or with hypoalbuminemia (i.e., less than 3.3 g/dl), the model was both precise and unbiased [11].
  • Creatinine clearance was normal in all cases. p-Aminohippurate clearance was decreased in two patients who had hypoalbuminemia [12].
  • Estrogen replacement during hypoalbuminemia may enhance atherosclerotic risk [13].
  • She had minimal renal insufficiency and hypoalbuminemia prior to initiation of methotrexate therapy, and had received a nonsteroidal anti-inflammatory drug concurrently [14].
  • Consistent with the physiologic hypoalbuminemia of pregnancy, serum albumin concentrations averaged only 3.2 +/- 0.3 gm/dl (+/- SD) in pregnant subjects, compared with 4.4 +/- 0.3 gm/dl in control subjects (p less than 1 x 10(-6], and this was the main cause of decreased theophylline binding [15].

Biological context of Hypoalbuminemia


Anatomical context of Hypoalbuminemia


Gene context of Hypoalbuminemia

  • Evaluation of the acute phase response by measurement of CRP is advisable in the evaluation of hypoalbuminemia or other stigmata of malnutrition in dialysis patients [26].
  • The MMP-3 levels were significantly higher in SLE patients who had a history of the following abnormalities: persistent proteinuria, cellular casts, anti-double stranded DNA antibodies, decreased C3, decreased creatinine clearance (p < 0.001), circulating immune complex (p < 0.01), malar rash, hypoalbuminemia, or decreased C4 (p < 0.05) [27].
  • In contrast, despite extreme hypoalbuminemia, NAR showed normal FENa, increased urinary NOx excretion and upregulations of iNOS and nNOS protein abundance in the kidney [28].
  • Somatostatin and growth hormone inhibited inflammatory mediators and TNF alpha mRNA overexpressions, reduced the risk of MODS, corrected hypoalbuminemia, reversed negative nitrogen balance, and controlled the reduction of cell groups with functions and reasonably intervened SIRS caused by ANP [29].
  • Serum alpha 2-macroglobulin and alpha 1-inhibitor 3 concentrations are increased in hypoalbuminemia by post-transcriptional mechanisms [30].

Analytical, diagnostic and therapeutic context of Hypoalbuminemia


  1. Isoniazid-related liver disease. Occurrence with portal hypertension, hypoalbuminemia, and hypersplenism. Graham, W.G., Dundas, G.R. JAMA (1979) [Pubmed]
  2. Hypocalcemia-induced pustular psoriasis of von Zumbusch. New experience with an old syndrome. Stewart, A.F., Battaglini-Sabetta, J., Millstone, L. Ann. Intern. Med. (1984) [Pubmed]
  3. A new syndrome: ascites, hyperbilirubinemia, and hypoalbuminemia after biochemical modulation of fluorouracil with N-phosphonacetyl-L-aspartate (PALA). Kemeny, N., Seiter, K., Martin, D., Urmacher, C., Niedzwiecki, D., Kurtz, R.C., Costa, P., Murray, M. Ann. Intern. Med. (1991) [Pubmed]
  4. Release of arachidonic acid from human platelets. A key role for the potentiation of platelet aggregability in normal subjects as well as in those with nephrotic syndrome. Yoshida, N., Aoki, N. Blood (1978) [Pubmed]
  5. Graded effects of proteinuria on HDL structure in nephrotic rats. Shearer, G.C., Newman, J.W., Hammock, B.D., Kaysen, G.A. J. Am. Soc. Nephrol. (2005) [Pubmed]
  6. Early-onset ataxia with ocular motor apraxia and hypoalbuminemia: the aprataxin gene mutations. Shimazaki, H., Takiyama, Y., Sakoe, K., Ikeguchi, K., Niijima, K., Kaneko, J., Namekawa, M., Ogawa, T., Date, H., Tsuji, S., Nakano, I., Nishizawa, M. Neurology (2002) [Pubmed]
  7. Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene. Date, H., Onodera, O., Tanaka, H., Iwabuchi, K., Uekawa, K., Igarashi, S., Koike, R., Hiroi, T., Yuasa, T., Awaya, Y., Sakai, T., Takahashi, T., Nagatomo, H., Sekijima, Y., Kawachi, I., Takiyama, Y., Nishizawa, M., Fukuhara, N., Saito, K., Sugano, S., Tsuji, S. Nat. Genet. (2001) [Pubmed]
  8. Pretranslational regulation of albumin synthesis in tumor-bearing mice. The role of anorexia and undernutrition. Andersson, C.E., Lönnroth, I.C., Gelin, L.J., Moldawer, L.L., Lundholm, K.G. Gastroenterology (1991) [Pubmed]
  9. Alpha 1-antitrypsin excretion in stool in normal subjects and in patients with gastrointestinal disorders. Strygler, B., Nicar, M.J., Santangelo, W.C., Porter, J.L., Fordtran, J.S. Gastroenterology (1990) [Pubmed]
  10. The influence of albumin and calcium on human platelet arachidonic acid metabolism. Stuart, M.J., Gerrard, J.M., White, J.G. Blood (1980) [Pubmed]
  11. Prospective evaluation of a model for predicting etoposide plasma protein binding in cancer patients. Stewart, C.F., Fleming, R.A., Arbuck, S.G., Evans, W.E. Cancer Res. (1990) [Pubmed]
  12. Renal involvement in human trichinosis. Sitprija, V., Keoplung, M., Boonpucknavig, V., Boonpucknavig, S. Arch. Intern. Med. (1980) [Pubmed]
  13. Estrogen replacement during hypoalbuminemia may enhance atherosclerotic risk. Joles, J.A., Bijleveld, C., van Tol, A., Geelen, M.J., Koomans, H.A. J. Am. Soc. Nephrol. (1997) [Pubmed]
  14. Methotrexate-associated, early-onset pancytopenia in rheumatoid arthritis. Doolittle, G.C., Simpson, K.M., Lindsley, H.B. Arch. Intern. Med. (1989) [Pubmed]
  15. Characterization of theophylline binding to serum proteins in pregnant and nonpregnant women. Connelly, T.J., Ruo, T.I., Frederiksen, M.C., Atkinson, A.J. Clin. Pharmacol. Ther. (1990) [Pubmed]
  16. Prevalence of and factors associated with suboptimal care before initiation of dialysis in the United States. Obrador, G.T., Ruthazer, R., Arora, P., Kausz, A.T., Pereira, B.J. J. Am. Soc. Nephrol. (1999) [Pubmed]
  17. Antipyrine and warfarin disposition in a patient with idiopathic hypoalbuminemia. Piroli, R.J., Passananti, G.T., Shively, C.A., Vesell, E.S. Clin. Pharmacol. Ther. (1981) [Pubmed]
  18. Molecular mechanisms of altered cholesterol metabolism in rats with spontaneous focal glomerulosclerosis. Vaziri, N.D., Sato, T., Liang, K. Kidney Int. (2003) [Pubmed]
  19. Renal function in obstructive jaundice in man: cholangiocarcinoma model. Sitprija, V., Kashemsant, U., Sriratanaban, A., Arthachinta, S., Poshyachinda, V. Kidney Int. (1990) [Pubmed]
  20. Prevalence of acidosis and inflammation and their association with low serum albumin in chronic kidney disease. Eustace, J.A., Astor, B., Muntner, P.M., Ikizler, T.A., Coresh, J. Kidney Int. (2004) [Pubmed]
  21. Theoretical consideration of the effects of dilution on estimates of free thyroid hormones in serum. Kamikubo, K., Komaki, T., Nakamura, S., Sakata, S., Yasuda, K., Miura, K. Clin. Chem. (1984) [Pubmed]
  22. Mechanisms and implications of hypoalbuminemia in head-injured patients. McClain, C.J., Hennig, B., Ott, L.G., Goldblum, S., Young, A.B. J. Neurosurg. (1988) [Pubmed]
  23. Extracellular volume, nutritional status, and refeeding changes. Guirao, X., Franch, G., Gil, M.J., García-Domingo, M.I., Girvent, M., Sitges-Serra, A. Nutrition (Burbank, Los Angeles County, Calif.) (1994) [Pubmed]
  24. Multiple myeloma--complete remission with high dose melphalan chemotherapy. Richards, F., Coleman, M., Cooper, M.R., Ballard, W.P. Cancer Invest. (1985) [Pubmed]
  25. Clinical pathologic profiles of dogs and turkeys with congestive heart failure, either noninduced or induced by rapid ventricular pacing, and turkeys with furazolidone toxicosis. O'Brien, P.J., O'Grady, M., Lumsden, J.H., Holmberg, D.L., Shen, H., Weiler, J.E., Horn, R.D., Mirsalimi, S.M., Julian, R.J. Am. J. Vet. Res. (1993) [Pubmed]
  26. Inflammation nutritional state and outcome in end stage renal disease. Kaysen, G.A. Mineral and electrolyte metabolism. (1999) [Pubmed]
  27. Increased levels of matrix metalloproteinase-3 in sera from patients with active lupus nephritis. Kotajima, L., Aotsuka, S., Fujimani, M., Okawa-Takatsuji, M., Kinoshita, M., Sumiya, M., Obata, K. Clinical and experimental rheumatology. (1998) [Pubmed]
  28. Downregulation of nitric oxide synthase in nephrotic syndrome: role of proteinuria. Ni, Z., Vaziri, N.D. Biochim. Biophys. Acta (2003) [Pubmed]
  29. Mechanisms of multiple organ damages in acute necrotizing pancreatitis. Zhang, Q., Ni, Q., Cai, D., Zhang, Y., Zhang, N., Hou, L. Chin. Med. J. (2001) [Pubmed]
  30. Serum alpha 2-macroglobulin and alpha 1-inhibitor 3 concentrations are increased in hypoalbuminemia by post-transcriptional mechanisms. Stevenson, F.T., Greene, S., Kaysen, G.A. Kidney Int. (1998) [Pubmed]
  31. Anticachectin/tumor necrosis factor-alpha antibodies attenuate development of cachexia in tumor models. Sherry, B.A., Gelin, J., Fong, Y., Marano, M., Wei, H., Cerami, A., Lowry, S.F., Lundholm, K.G., Moldawer, L.L. FASEB J. (1989) [Pubmed]
  32. Autoimmune hepatitis/sclerosing cholangitis overlap syndrome in childhood: a 16-year prospective study. Gregorio, G.V., Portmann, B., Karani, J., Harrison, P., Donaldson, P.T., Vergani, D., Mieli-Vergani, G. Hepatology (2001) [Pubmed]
  33. Tryptophan, tube-feeding, and hypoalbuminemia. Graham, G.G. Am. J. Clin. Nutr. (1991) [Pubmed]
  34. Randomized, double-blind study of intravenous human albumin in hypoalbuminemic patients receiving total parenteral nutrition. Rubin, H., Carlson, S., DeMeo, M., Ganger, D., Craig, R.M. Crit. Care Med. (1997) [Pubmed]
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