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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cell response in bronchoalveolar lavage fluid after sulfur dioxide exposure.

Environmental chamber exposure and bronchoalveolar lavage (BAL) were used to study the dose-response relationship between short-term exposure to sulfur dioxide (SO2) and inflammatory reactions in the human lung as reflected in BAL fluid. Healthy subjects were exposed to 10, 13, 20, or 30 mg/m3 for 20 min. BAL was performed several weeks preexposure and 24 h postexposure. Mast cells, lymphocytes, lysozyme positive macrophages, and the total number of macrophages were significantly increased after SO2 exposure. A dose-dependent increase in the cell response in BAL fluid was observed after exposure to 10-20 mg/m3, but no further increase was detected after 30 mg/m3. Inflammatory cell response was found in BAL fluid at SO2 levels that occur in industrial indoor environments worldwide, and cell response to SO2 was also seen below the short-term exposure limit of Sweden and many other countries (13 mg/m3).[1]


  1. Cell response in bronchoalveolar lavage fluid after sulfur dioxide exposure. Sandström, T., Stjernberg, N., Andersson, M.C., Kolmodin-Hedman, B., Lindström, K., Rosenhall, L. Scandinavian journal of work, environment & health. (1989) [Pubmed]
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