The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

About

Terms

 

 
 
 
 

2-Amino-6-trifluoromethoxy benzothiazole (PK 26124), a proposed antagonist of excitatory amino acid neurotransmission, does not produce phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys.

PK 26124, a proposed excitatory amino acid antagonist, was compared to mephenesin and phencyclidine (PCP). In pigeons, PK 26124 and mephenesin produced loss of righting that was to some extent associated with eye closure and muscle relaxation, whereas PCP produced catalepsy, i.e., loss of righting without eye closure and without muscle relaxation. PK 26124, but not mephenesin, produced PCP-like discriminative stimulus effects in some but not all pigeons. In rats, PK 26124 and mephenesin produced loss of righting but did not induce locomotion, sniffing, swaying and falling, unlike PCP. In rhesus monkeys, PK 26124 did not induce ketamine-like discriminative stimulus effects. While PK 26124 may share some biochemical properties with excitatory amino acid antagonists these do not lead to behavioral effects similar to PCP.[1]

References

  1. 2-Amino-6-trifluoromethoxy benzothiazole (PK 26124), a proposed antagonist of excitatory amino acid neurotransmission, does not produce phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys. Koek, W., Woods, J.H. Neuropharmacology (1988) [Pubmed]
Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities