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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Identification of inosine and hypoxanthine as endogenous ligands for the brain benzodiazepine-binding sites.

Two endogenous ligands for the brain benzodiazepine-binding sites were isolated from bovine brain through gel filtration, paper electrophoresis, and paper chromatography. These ligands were identified as inosine and hypoxanthine, and both had a higher affinity for the brain benzodiazepine-binding sites than for benzodiazepine sites in some peripheral tissues. They did not bind to any other receptors tested, such as the opiate, muscarinic cholinergic, gamma-aminobutyric acid, and beta-adrenergic receptors. Both inosine and hypoxanthine competitively inhibited the binding of [3H]diazepam to the brain binding site.[1]

References

  1. Identification of inosine and hypoxanthine as endogenous ligands for the brain benzodiazepine-binding sites. Asano, T., Spector, S. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
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