Translational regulation of myelin protein synthesis by steroids.
Various steroids, including glucocorticoids, were observed to exert a direct effect on the rates of translation of several myelin-protein specific transcripts in a cell-free, reticulocyte lysate system. Hydrocortisone caused a twofold stimulation in the translation of mRNAs of myelin basic protein and proteolipid protein. It inhibited the translation of 2',3'-cyclic nucleotide 3'-phosphodiesterase mRNA by 50%, and had no effect on the translation of a number of other mRNAs. The data suggest that steroid-mediated translational regulation may serve as a novel mechanism to modulate the expression of myelin protein genes at the translational level.[1]References
- Translational regulation of myelin protein synthesis by steroids. Verdi, J.M., Kampf, K., Campagnoni, A.T. J. Neurochem. (1989) [Pubmed]
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