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Gene Review

Mbp  -  myelin basic protein

Mus musculus

Synonyms: C76307, Hmbpr, MBP, Myelin A1 protein, Myelin basic protein, ...
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Disease relevance of Mbp


Psychiatry related information on Mbp

  • Shiverer clearly showed deficits in successive reversal learning, while mld showed less deficits in the learning performance [6].

High impact information on Mbp


Chemical compound and disease context of Mbp


Biological context of Mbp

  • Regulation of cytoskeleton by myelin components: studies on shiverer oligodendrocytes carrying an Mbp transgene [16].
  • The present work demonstrates that these IL6RIL6-treated F10.9 cells undergo transdifferentiation to a myelinating glial phenotype characterized by induction of the transcriptional activities of both Po and MBP promoters and accumulation of myelin gene products [17].
  • These results indicate that the jp, jpmsd, and qk mutations exhibit qualitatively similar phenotypic effects on MBP gene expression but the magnitude of the effect is proportional to the extent of hypomyelination in each mutant [18].
  • Additionally, major histocompatibility complex (MHC) class I and class II mRNA levels were increased in the CNS of MBP/IFN-gamma transgenic mice, and the increase in MHC class I mRNA expression was detected in both white and gray matter regions [19].
  • Thus, cytokine plasmid treatment appeared to inhibit MBP-specific pathogenic Thl responses, while enhancing endogenous secretion of protective cytokines [20].

Anatomical context of Mbp


Associations of Mbp with chemical compounds

  • Doxycycline-regulated overexpression of C/EBP-delta was sufficient to induce accumulation of P0 and MBP mRNAs, the effect being selective, because C/EBP-delta did not affect several other genes strongly regulated by IL6RIL6 [22].
  • Comparing the extent of total methylation in vivo (sum of all three arginine derivatives), MBP extracted from less-compact myelin (P3A and P3B) showed a level approx. 40% higher than that from compact myelin [23].
  • By contrast, the concentrations of P0 glycoprotein and myelin basic proteins were reduced to 27% and 20% of control levels, respectively [24].
  • MBPs isolated from dysmyelinating mutant mouse brains, such as jimpy (jp/y) and quaking (qk/qk), contained a much higher level of Me2(asym)Arg relative to the other two methyl derivatives and also in comparison with those levels in the mother brain MBP [23].
  • The amounts of NG-methylarginine derivatives in myelin basic protein (MBP) purified from dysmyelinating mutant and different stages of normal myelinating mouse brains have been studied by using h.p.l.c. with a highly sensitive post-column o-phthaldialdehyde derivative-formation method [23].

Physical interactions of Mbp


Enzymatic interactions of Mbp


Regulatory relationships of Mbp

  • Pax3 repressed a 1.3 kb MBP promoter fragment in cotransfection assays, suggesting that it represses MBP transcription [35].
  • In contrast to oral tolerization, s.c. immunization of transgenic animals with MBP in complete Freund's adjuvant induced IFN-gamma-secreting Th1 cells in vitro and experimental encephalomyelitis in vivo [1].
  • Inhibition of female T cell contact-mediated microglial expression of proinflammatory molecules by dominant-negative mutants of p65 and C/EBPbeta suggest that female MBP-primed T cells induce microglial expression of proinflammatory molecules through the activation of NF-kappaB and C/EBPbeta [3].
  • MBP mRNA levels remained well below control levels in jp/Y brain polyribosomes throughout early postnatal development [36].
  • Our data suggest that incorporation of this MOBP isoform into shiverer myelin may be influenced by the presence of MBP or be a consequence of a disrupted MDL [37].

Other interactions of Mbp

  • At monthly intervals after immunization with p139-151, responses to PLP 249-273, MBP 87-99, and PLP 137-198 were sequentially accumulated in al mice examined [38].
  • An inverse correlation was observed between expression of Pax3 RNA and myelin basic protein (MBP) [35].
  • Furthermore, the developmental change between the two molecular forms of MAG (p72MAG/p67MAG) was delayed in mld mice [39].
  • However, the data suggest the presence of a peptide core between MBP 21-26 (HARHGF), which contains similar elements to the previously defined encephalitogenic MOG 1-22 and PLP 56-70 peptides [40].
  • These studies suggest that microglial activation of C/EBPbeta but not NF-kappaB by T cell:microglial contact is a gender-specific event and that male MBP-primed T cells are not capable of inducing microglial expression of proinflammatory molecules due to their inability to induce the activation of C/EBPbeta in microglia [3].

Analytical, diagnostic and therapeutic context of Mbp

  • In the present study, we investigated the cellular requirements for the generation of active suppression following oral administration of MBP in SJL and (PLJ x SJL)F1 mice [2].
  • Total messenger RNA (mRNA) and myelin basic protein (MBP)-specific mRNA from brains of these three mutants have been analyzed by in vitro translation and immunoprecipitation with antibody to MBP [18].
  • The MBP-related polypeptides that accumulate in vivo have also been analyzed in the three mutants by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) followed by immunoblotting with antibody to MBP [18].
  • However, MBP and PLP polypeptides could not be detected by western blot or immunocytochemical staining at either the permissive or nonpermissive temperature [41].
  • In general, the MBP mRNA levels measured directly by Northern blot and "dot" blot analyses correlated well with the indirect in vitro translation measurements [36].


  1. Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells. Chen, Y., Inobe, J., Kuchroo, V.K., Baron, J.L., Janeway, C.A., Weiner, H.L. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  2. Induction of oral tolerance to myelin basic protein in CD8-depleted mice: both CD4+ and CD8+ cells mediate active suppression. Chen, Y., Inobe, J., Weiner, H.L. J. Immunol. (1995) [Pubmed]
  3. Myelin basic protein-primed T cells of female but not male mice induce nitric-oxide synthase and proinflammatory cytokines in microglia: implications for gender bias in multiple sclerosis. Dasgupta, S., Jana, M., Liu, X., Pahan, K. J. Biol. Chem. (2005) [Pubmed]
  4. Chronic relapsing experimental autoimmune encephalomyelitis with a delayed onset and an atypical clinical course, induced in PL/J mice by myelin oligodendrocyte glycoprotein (MOG)-derived peptide: preliminary analysis of MOG T cell epitopes. Kerlero de Rosbo, N., Mendel, I., Ben-Nun, A. Eur. J. Immunol. (1995) [Pubmed]
  5. Selective expression of foreign genes in glioma cells: use of the mouse myelin basic protein gene promoter to direct toxic gene expression. Miyao, Y., Shimizu, K., Moriuchi, S., Yamada, M., Nakahira, K., Nakajima, K., Nakao, J., Kuriyama, S., Tsujii, T., Mikoshiba, K. J. Neurosci. Res. (1993) [Pubmed]
  6. The role of myelination in learning performance observed in two strains of myelin-deficient mutant mice (shiverer and mld). Inagawa, K., Watanabe, S., Tsukada, Y., Mikoshiba, K. Behavioral and neural biology. (1988) [Pubmed]
  7. High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Lafaille, J.J., Nagashima, K., Katsuki, M., Tonegawa, S. Cell (1994) [Pubmed]
  8. Mapping loci influencing the persistence of Theiler's virus in the murine central nervous system. Bureau, J.F., Montagutelli, X., Bihl, F., Lefebvre, S., Guénet, J.L., Brahic, M. Nat. Genet. (1993) [Pubmed]
  9. Myelin deficient mice: expression of myelin basic protein and generation of mice with varying levels of myelin. Popko, B., Puckett, C., Lai, E., Shine, H.D., Readhead, C., Takahashi, N., Hunt, S.W., Sidman, R.L., Hood, L. Cell (1987) [Pubmed]
  10. Expression of a myelin basic protein gene in transgenic shiverer mice: correction of the dysmyelinating phenotype. Readhead, C., Popko, B., Takahashi, N., Shine, H.D., Saavedra, R.A., Sidman, R.L., Hood, L. Cell (1987) [Pubmed]
  11. Oral tolerance to copolymer 1 in myelin basic protein (MBP) TCR transgenic mice: cross-reactivity with MBP-specific TCR and differential induction of anti-inflammatory cytokines. Maron, R., Slavin, A.J., Hoffmann, E., Komagata, Y., Weiner, H.L. Int. Immunol. (2002) [Pubmed]
  12. Vaccination for protection of retinal ganglion cells against death from glutamate cytotoxicity and ocular hypertension: implications for glaucoma. Schori, H., Kipnis, J., Yoles, E., WoldeMussie, E., Ruiz, G., Wheeler, L.A., Schwartz, M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  13. Peroxisome proliferator-activated receptor-gamma agonists prevent experimental autoimmune encephalomyelitis. Feinstein, D.L., Galea, E., Gavrilyuk, V., Brosnan, C.F., Whitacre, C.C., Dumitrescu-Ozimek, L., Landreth, G.E., Pershadsingh, H.A., Weinberg, G., Heneka, M.T. Ann. Neurol. (2002) [Pubmed]
  14. Functional analysis of the mouse myelin/oligodendrocyte glycoprotein gene promoter in the oligodendroglial CG4 cell line. Solly, S.K., Daubas, P., Monge, M., Dautigny, A., Zalc, B. J. Neurochem. (1997) [Pubmed]
  15. Tumor necrosis factor modulates transcription of myelin basic protein gene through nuclear factor kappa B in a human oligodendroglioma cell line. Huang, C.J., Nazarian, R., Lee, J., Zhao, P.M., Espinosa-Jeffrey, A., de Vellis, J. Int. J. Dev. Neurosci. (2002) [Pubmed]
  16. Regulation of cytoskeleton by myelin components: studies on shiverer oligodendrocytes carrying an Mbp transgene. Dyer, C.A., Phillbotte, T., Wolf, M.K., Billings-Gagliardi, S. Dev. Neurosci. (1997) [Pubmed]
  17. Activation of myelin genes during transdifferentiation from melanoma to glial cell phenotype. Slutsky, S.G., Kamaraju, A.K., Levy, A.M., Chebath, J., Revel, M. J. Biol. Chem. (2003) [Pubmed]
  18. Myelin basic protein gene expression in quaking, jimpy, and myelin synthesis-deficient mice. Carnow, T.B., Carson, J.H., Brostoff, S.W., Hogan, E.L. Dev. Biol. (1984) [Pubmed]
  19. Targeted CNS expression of interferon-gamma in transgenic mice leads to hypomyelination, reactive gliosis, and abnormal cerebellar development. Corbin, J.G., Kelly, D., Rath, E.M., Baerwald, K.D., Suzuki, K., Popko, B. Mol. Cell. Neurosci. (1996) [Pubmed]
  20. Prevention of experimental allergic encephalomyelitis by intramuscular gene transfer with cytokine-encoding plasmid vectors. Piccirillo, C.A., Prud'homme, G.J. Hum. Gene Ther. (1999) [Pubmed]
  21. Myelin basic protein gene dosage effects in the PNS. Smith-Slatas, C., Barbarese, E. Mol. Cell. Neurosci. (2000) [Pubmed]
  22. C/EBP-delta induction by gp130 signaling. Role in transition to myelin gene expressing phenotype in a melanoma cell line model. Kamaraju, A.K., Adjalley, S., Zhang, P., Chebath, J., Revel, M. J. Biol. Chem. (2004) [Pubmed]
  23. Studies on NG-methylarginine derivatives in myelin basic protein from developing and mutant mouse brain. Rawal, N., Lee, Y.J., Paik, W.K., Kim, S. Biochem. J. (1992) [Pubmed]
  24. Myelin-associated glycoprotein and other proteins in Trembler mice. Inuzuka, T., Quarles, R.H., Heath, J., Trapp, B.D. J. Neurochem. (1985) [Pubmed]
  25. Electron paramagnetic resonance spectroscopy and molecular modelling of the interaction of myelin basic protein (MBP) with calmodulin (CaM)-diversity and conformational adaptability of MBP CaM-targets. Polverini, E., Boggs, J.M., Bates, I.R., Harauz, G., Cavatorta, P. J. Struct. Biol. (2004) [Pubmed]
  26. Developmentally-programmed FMRP expression in oligodendrocytes: a potential role of FMRP in regulating translation in oligodendroglia progenitors. Wang, H., Ku, L., Osterhout, D.J., Li, W., Ahmadian, A., Liang, Z., Feng, Y. Hum. Mol. Genet. (2004) [Pubmed]
  27. Antibodies to myelin/oligodendrocyte-specific protein and myelin/oligodendrocyte glycoprotein signal distinct changes in the organization of cultured oligodendroglial membrane sheets. Dyer, C.A., Matthieu, J.M. J. Neurochem. (1994) [Pubmed]
  28. CNS myelinogenesis in vitro: myelin basic protein deficient shiverer oligodendrocytes. Seiwa, C., Kojima-Aikawa, K., Matsumoto, I., Asou, H. J. Neurosci. Res. (2002) [Pubmed]
  29. A phase I trial of solubilized DR2:MBP84-102 (AG284) in multiple sclerosis. Goodkin, D.E., Shulman, M., Winkelhake, J., Waubant, E., Andersson, P., Stewart, T., Nelson, S., Fischbein, N., Coyle, P.K., Frohman, E., Jacobs, L., Holcenberg, J., Lee, M., Mocci, S. Neurology (2000) [Pubmed]
  30. Myelin basic protein and myelin-associated glycoprotein in chronic, relapsing experimental allergic encephalomyelitis. Sternberger, N.H., McFarlin, D.E., Traugott, U., Raine, C.S. J. Neuroimmunol. (1984) [Pubmed]
  31. Mitogen-activated Swiss mouse 3T3 RSK kinases I and II are related to pp44mpk from sea star oocytes and participate in the regulation of pp90rsk activity. Chung, J., Pelech, S.L., Blenis, J. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  32. Multiple cDNAs encoding the esk kinase predict transmembrane and intracellular enzyme isoforms. Douville, E.M., Afar, D.E., Howell, B.W., Letwin, K., Tannock, L., Ben-David, Y., Pawson, T., Bell, J.C. Mol. Cell. Biol. (1992) [Pubmed]
  33. Cellular trafficking of the IL-1RI-associated kinase-1 requires intact kinase activity. Böl, G.F., Jurrmann, N., Brigelius-Flohé, R. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  34. Gelatinase B is present in the cerebrospinal fluid during experimental autoimmune encephalomyelitis and cleaves myelin basic protein. Gijbels, K., Proost, P., Masure, S., Carton, H., Billiau, A., Opdenakker, G. J. Neurosci. Res. (1993) [Pubmed]
  35. Pax3: a paired domain gene as a regulator in PNS myelination. Kioussi, C., Gross, M.K., Gruss, P. Neuron (1995) [Pubmed]
  36. Expression of myelin basic protein genes in several dysmyelinating mouse mutants during early postnatal brain development. Roth, H.J., Hunkeler, M.J., Campagnoni, A.T. J. Neurochem. (1985) [Pubmed]
  37. Reduced levels of a specific myelin-associated oligodendrocytic basic protein isoform in shiverer myelin. Montague, P., Kirkham, D., McCallion, A.S., Davies, R.W., Kennedy, P.G., Klugmann, M., Nave, K., Griffiths, I.R. Dev. Neurosci. (1999) [Pubmed]
  38. A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: a basis for peptide-specific therapy after onset of clinical disease. Yu, M., Johnson, J.M., Tuohy, V.K. J. Exp. Med. (1996) [Pubmed]
  39. Myelin instability and oligodendrocyte metabolism in myelin-deficient mutant mice. Matthieu, J.M., Roch, J.M., Omlin, F.X., Rambaldi, I., Almazan, G., Braun, P.E. J. Cell Biol. (1986) [Pubmed]
  40. Encephalitogenic epitopes of myelin basic protein, proteolipid protein, myelin oligodendrocyte glycoprotein for experimental allergic encephalomyelitis induction in Biozzi ABH (H-2Ag7) mice share an amino acid motif. Amor, S., O'Neill, J.K., Morris, M.M., Smith, R.M., Wraith, D.C., Groome, N., Travers, P.J., Baker, D. J. Immunol. (1996) [Pubmed]
  41. Expression of myelin protein genes and other myelin components in an oligodendrocytic cell line conditionally immortalized with a temperature-sensitive retrovirus. Verity, A.N., Bredesen, D., Vonderscher, C., Handley, V.W., Campagnoni, A.T. J. Neurochem. (1993) [Pubmed]
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