The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Atp6v0c  -  ATPase, H+ transporting, lysosomal V0...

Mus musculus

Synonyms: Atp6c, Atp6c2, Atp6l, Atpl, Atpl-rs1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Atp6v0c


High impact information on Atp6v0c

  • Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene [6].
  • The structural gene coding for myelin-associated proteolipid protein is mutated in jimpy mice [7].
  • Axonal swellings and degeneration in mice lacking the major proteolipid of myelin [8].
  • To ascertain this hypothesis 129 x C57BL/6 mice with an inactivation of the tnf and lta genes (129 x C57BL/6(-/-)) and SJL/J mice derived from backcrosses of the above mentioned mutant mice (SJL-/-) were immunized with mouse spinal cord homogenate (MSCH) or proteolipid protein [9].
  • We investigate here the mechanisms by which in vivo abrogation of leptin effects protects SJL/J mice from proteolipid protein peptide PLP(139-151)-induced EAE, an animal model of MS [10].

Chemical compound and disease context of Atp6v0c


Biological context of Atp6v0c


Anatomical context of Atp6v0c


Associations of Atp6v0c with chemical compounds


Physical interactions of Atp6v0c


Regulatory relationships of Atp6v0c


Other interactions of Atp6v0c


Analytical, diagnostic and therapeutic context of Atp6v0c


  1. Transgenic expression of CCL2 in the central nervous system prevents experimental autoimmune encephalomyelitis. Elhofy, A., Wang, J., Tani, M., Fife, B.T., Kennedy, K.J., Bennett, J., Huang, D., Ransohoff, R.M., Karpus, W.J. J. Leukoc. Biol. (2005) [Pubmed]
  2. Biology of oligodendrocyte and myelin in the mammalian central nervous system. Baumann, N., Pham-Dinh, D. Physiol. Rev. (2001) [Pubmed]
  3. Treatment of experimental encephalomyelitis with a novel chimeric fusion protein of myelin basic protein and proteolipid protein. Elliott, E.A., McFarland, H.I., Nye, S.H., Cofiell, R., Wilson, T.M., Wilkins, J.A., Squinto, S.P., Matis, L.A., Mueller, J.P. J. Clin. Invest. (1996) [Pubmed]
  4. Endogenous presentation of self myelin epitopes by CNS-resident APCs in Theiler's virus-infected mice. Katz-Levy, Y., Neville, K.L., Girvin, A.M., Vanderlugt, C.L., Pope, J.G., Tan, L.J., Miller, S.D. J. Clin. Invest. (1999) [Pubmed]
  5. Hla-DR2-restricted responses to proteolipid protein 95-116 peptide cause autoimmune encephalitis in transgenic mice. Kawamura, K., Yamamura, T., Yokoyama, K., Chui, D.H., Fukui, Y., Sasazuki, T., Inoko, H., David, C.S., Tabira, T. J. Clin. Invest. (2000) [Pubmed]
  6. Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene. Schneider, A., Montague, P., Griffiths, I., Fanarraga, M., Kennedy, P., Brophy, P., Nave, K.A. Nature (1992) [Pubmed]
  7. The structural gene coding for myelin-associated proteolipid protein is mutated in jimpy mice. Dautigny, A., Mattei, M.G., Morello, D., Alliel, P.M., Pham-Dinh, D., Amar, L., Arnaud, D., Simon, D., Mattei, J.F., Guenet, J.L. Nature (1986) [Pubmed]
  8. Axonal swellings and degeneration in mice lacking the major proteolipid of myelin. Griffiths, I., Klugmann, M., Anderson, T., Yool, D., Thomson, C., Schwab, M.H., Schneider, A., Zimmermann, F., McCulloch, M., Nadon, N., Nave, K.A. Science (1998) [Pubmed]
  9. Tumor necrosis factor alpha and lymphotoxin alpha are not required for induction of acute experimental autoimmune encephalomyelitis. Frei, K., Eugster, H.P., Bopst, M., Constantinescu, C.S., Lavi, E., Fontana, A. J. Exp. Med. (1997) [Pubmed]
  10. Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis. De Rosa, V., Procaccini, C., La Cava, A., Chieffi, P., Nicoletti, G.F., Fontana, S., Zappacosta, S., Matarese, G. J. Clin. Invest. (2006) [Pubmed]
  11. Overexpression of the myelin proteolipid protein leads to accumulation of cholesterol and proteolipid protein in endosomes/lysosomes: implications for Pelizaeus-Merzbacher disease. Simons, M., Kramer, E.M., Macchi, P., Rathke-Hartlieb, S., Trotter, J., Nave, K.A., Schulz, J.B. J. Cell Biol. (2002) [Pubmed]
  12. CLN3P, the Batten's disease protein, is a novel palmitoyl-protein Delta-9 desaturase. Narayan, S.B., Rakheja, D., Tan, L., Pastor, J.V., Bennett, M.J. Ann. Neurol. (2006) [Pubmed]
  13. Altered peptide ligand modulation of experimental allergic encephalomyelitis: immune responses within the CNS. Santambrogio, L., Lees, M.B., Sobel, R.A. J. Neuroimmunol. (1998) [Pubmed]
  14. Chromosomal localization of three vacuolar-H+ -ATPase 16 kDa subunit (ATP6V0C) genes in the murine genome. Simckes, A.M., Swanson, S.K., White, R.A. Cytogenet. Genome Res. (2002) [Pubmed]
  15. Acidic endomembrane organelles are required for mouse postimplantation development. Sun-Wada, G., Murata, Y., Yamamoto, A., Kanazawa, H., Wada, Y., Futai, M. Dev. Biol. (2000) [Pubmed]
  16. The murine genome contains one functional gene and two pseudogenes coding for the 16 kDa proteolipid subunit of vacuolar H(+)-ATPase. Hayami, K., Noumi, T., Inoue, H., Sun-Wada, G., Yoshimizu, T., Kanazawa, H. Gene (2001) [Pubmed]
  17. The potential for oligodendrocyte proliferation during demyelinating disease. Prayoonwiwat, N., Rodriguez, M. J. Neuropathol. Exp. Neurol. (1993) [Pubmed]
  18. Disorders in myelination in the twitcher mutant: immunohistochemical and biochemical studies. Mikoshiba, K., Fujishiro, M., Kohsaka, S., Okano, H., Takamatsu, K., Tsukada, Y. Neurochem. Res. (1985) [Pubmed]
  19. The transmembrane semaphorin Sema4D/CD100, an inhibitor of axonal growth, is expressed on oligodendrocytes and upregulated after CNS lesion. Moreau-Fauvarque, C., Kumanogoh, A., Camand, E., Jaillard, C., Barbin, G., Boquet, I., Love, C., Jones, E.Y., Kikutani, H., Lubetzki, C., Dusart, I., Chédotal, A. J. Neurosci. (2003) [Pubmed]
  20. Assembly of CNS myelin in the absence of proteolipid protein. Klugmann, M., Schwab, M.H., Pühlhofer, A., Schneider, A., Zimmermann, F., Griffiths, I.R., Nave, K.A. Neuron (1997) [Pubmed]
  21. Assembly of myelin by association of proteolipid protein with cholesterol- and galactosylceramide-rich membrane domains. Simons, M., Krämer, E.M., Thiele, C., Stoffel, W., Trotter, J. J. Cell Biol. (2000) [Pubmed]
  22. Role of calnexin in the glycan-independent quality control of proteolipid protein. Swanton, E., High, S., Woodman, P. EMBO J. (2003) [Pubmed]
  23. Changes in calcium channel activity in membranes from cis-diammine-dichloroplatinum(II)-resistant and -sensitive L1210 cells. Vassilev, P.M., Kanazirska, M.P., Charamella, L.J., Dimitrov, N.V., Tien, H.T. Cancer Res. (1987) [Pubmed]
  24. Translational regulation of myelin protein synthesis by steroids. Verdi, J.M., Kampf, K., Campagnoni, A.T. J. Neurochem. (1989) [Pubmed]
  25. Neurological mutation characterized by dysmyelination in NCTR-Balb/C mouse with lysosomal lipid storage disease. Weintraub, H., Abramovici, A., Sandbank, U., Pentchev, P.G., Brady, R.O., Sekine, M., Suzuki, A., Sela, B. J. Neurochem. (1985) [Pubmed]
  26. Brain-derived heat shock protein 70-peptide complexes induce NK cell-dependent tolerance to experimental autoimmune encephalomyelitis. Galazka, G., Stasiolek, M., Walczak, A., Jurewicz, A., Zylicz, A., Brosnan, C.F., Raine, C.S., Selmaj, K.W. J. Immunol. (2006) [Pubmed]
  27. Arrest of proteolipid transport through the Golgi apparatus in Jimpy brain. Roussel, G., Neskovic, N.M., Trifilieff, E., Artault, J.C., Nussbaum, J.L. J. Neurocytol. (1987) [Pubmed]
  28. IL-4 abrogates the inhibitory effect of IL-10 on the development of experimental allergic encephalomyelitis in SJL mice. Nagelkerken, L., Blauw, B., Tielemans, M. Int. Immunol. (1997) [Pubmed]
  29. Programmed cell death without DNA fragmentation in the jimpy mouse: secreted factors can enhance survival. Knapp, P.E., Bartlett, W.P., Williams, L.A., Yamada, M., Ikenaka, K., Skoff, R.P. Cell Death Differ. (1999) [Pubmed]
  30. Amelioration of experimental autoimmune encephalomyelitis with anti-OX40 ligand monoclonal antibody: a critical role for OX40 ligand in migration, but not development, of pathogenic T cells. Nohara, C., Akiba, H., Nakajima, A., Inoue, A., Koh, C.S., Ohshima, H., Yagita, H., Mizuno, Y., Okumura, K. J. Immunol. (2001) [Pubmed]
  31. Therapy with antibodies against CD40L (CD154) and CD44-variant isoforms reduces experimental autoimmune encephalomyelitis induced by a proteolipid protein peptide. Laman, J.D., Maassen, C.B., Schellekens, M.M., Visser, L., Kap, M., de Jong, E., van Puijenbroek, M., van Stipdonk, M.J., van Meurs, M., Schwärzler, C., Günthert, U. Mult. Scler. (1998) [Pubmed]
  32. Mouse Atp6f, the gene encoding the 23-kDa proteolipid of vacuolar proton translocating ATPase. Sun-Wada, G.H., Murakami, H., Nakai, H., Wada, Y., Futai, M. Gene (2001) [Pubmed]
  33. Complement C5 in experimental autoimmune encephalomyelitis (EAE) facilitates remyelination and prevents gliosis. Weerth, S.H., Rus, H., Shin, M.L., Raine, C.S. Am. J. Pathol. (2003) [Pubmed]
  34. Molecular mechanisms involved in lymphocyte recruitment in inflamed brain microvessels: critical roles for P-selectin glycoprotein ligand-1 and heterotrimeric G(i)-linked receptors. Piccio, L., Rossi, B., Scarpini, E., Laudanna, C., Giagulli, C., Issekutz, A.C., Vestweber, D., Butcher, E.C., Constantin, G. J. Immunol. (2002) [Pubmed]
  35. Encephalitogenic epitopes of myelin basic protein, proteolipid protein, myelin oligodendrocyte glycoprotein for experimental allergic encephalomyelitis induction in Biozzi ABH (H-2Ag7) mice share an amino acid motif. Amor, S., O'Neill, J.K., Morris, M.M., Smith, R.M., Wraith, D.C., Groome, N., Travers, P.J., Baker, D. J. Immunol. (1996) [Pubmed]
  36. Parallel evolution and coexpression of the proteolipid proteins and protein zero in vertebrate myelin. Yoshida, M., Colman, D.R. Neuron (1996) [Pubmed]
  37. Expression and localization of the mouse homologue of the yeast V-ATPase 21-kDa Subunit c" (Vma16p). Nishi, T., Kawasaki-Nishi, S., Forgac, M. J. Biol. Chem. (2001) [Pubmed]
  38. Defective biosynthesis of proteolipid protein in Pelizaeus-Merzbacher disease. Koeppen, A.H., Ronca, N.A., Greenfield, E.A., Hans, M.B. Ann. Neurol. (1987) [Pubmed]
  39. Adoptive transfer of experimental allergic encephalomyelitis after in vitro treatment with recombinant murine interleukin-12. Preferential expansion of interferon-gamma-producing cells and increased expression of macrophage-associated inducible nitric oxide synthase as immunomodulatory mechanisms. Waldburger, K.E., Hastings, R.C., Schaub, R.G., Goldman, S.J., Leonard, J.P. Am. J. Pathol. (1996) [Pubmed]
  40. Induction of antigen-specific tolerance for the treatment of ongoing, relapsing autoimmune encephalomyelitis: a comparison between oral and peripheral tolerance. Kennedy, K.J., Smith, W.S., Miller, S.D., Karpus, W.J. J. Immunol. (1997) [Pubmed]
  41. Interaction in vitro of nonepithelial intermediate filament proteins with total cellular lipids, individual phospholipids, and a phospholipid mixture. Traub, P., Perides, G., Schimmel, H., Scherbarth, A. J. Biol. Chem. (1986) [Pubmed]
WikiGenes - Universities