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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Ascorbate in aqueous humor protects against myeloperoxidase-induced oxidation.

Chemotactic factors can cause polymorphonuclear leukocytes to release the contents of azurophilic granules, including the enzymes beta-glucuronidase and myeloperoxidase. In the presence of aqueous humor from the anterior chamber of the rabbit eye, the supernatant from stimulated leukocytes contains beta-glucuronidase, but myeloperoxidase is not detectable. Studies with aqueous humor and partially purified human myeloperoxidase suggest that this phenomenon is not due to a failure of enzyme release. The factor responsible for the inability to detect MPO in the assay system is heat-labile, dialyzable, and reversed by ascorbate oxidase. Comparable assay inhibition is produced by ascorbic acid at a concentration present in either human or rabbit aqueous humor. The ability of aqueous humor to protect against myeloperoxidase-induced oxidation may contribute to several diverse phenomena, including the susceptibility of the eye to Candida infection and a prolonged half-life for several inflammatory mediators in the anterior chamber.[1]


  1. Ascorbate in aqueous humor protects against myeloperoxidase-induced oxidation. Rosenbaum, J.T., Howes, E.L., English, D. Am. J. Pathol. (1985) [Pubmed]
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