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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Anterior Chamber

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Disease relevance of Anterior Chamber


High impact information on Anterior Chamber

  • Rieger syndrome (RIEG) is an autosomal-dominant human disorder that includes anomalies of the anterior chamber of the eye, dental hypoplasia and a protuberant umbilicus [6].
  • Inflammatory cells entering the anterior chamber of the eye in response to viral infection underwent apoptosis that was dependent on Fas (CD95)-Fas ligand (FasL) and produced no tissue damage [7].
  • Systemic immune unresponsiveness induced in adult mice by anterior chamber presentation of minor histocompatibility antigens [8].
  • In addition, by 6 months none of the flubendazole subjects had intracorneal microfilariae, and only one had microfilariae in the anterior chamber, whereas the numbers of intraocular microfilariae in the DEC group had returned to pretreatment levels [9].
  • Here we describe the identification of novel mutations in the FOXC1 gene in patients with anterior-chamber defects of the eye [10].

Chemical compound and disease context of Anterior Chamber


Biological context of Anterior Chamber


Anatomical context of Anterior Chamber


Associations of Anterior Chamber with chemical compounds

  • Thus, a new role for the high ascorbate level present in the anterior chamber fluid and the lens has been suggested [25].
  • Medial amygdaloid tissue, taken from female rats immediately after birth, was transplanted into the anterior chamber of the eye in adult ovariectomized host rats in order to elucidate the influence of estrogen on synapse formation without contribution of neural afferents [26].
  • Administration of nerve growth factor (NGF) into the anterior chamber substantially increased both SP and TH activity in the iris and also increased CAT activity to a lesser extent [27].
  • Abnormalities were found in 14 (fluorescein leakage in 10, perivenous sheathing in 6, cells in the vitreous in 6 and in the anterior chamber in 4; in 2 the cells in the media were seen without vascular changes) [28].
  • These experiments reveal that voltage- and Na+ -dependent transport by S427L-hkNBCe1 is unfavorably altered, thereby causing both insufficient HCO3- absorption by the kidney (proximal RTA) and inappropriate anterior chamber fluid transport (glaucoma) [29].

Gene context of Anterior Chamber


Analytical, diagnostic and therapeutic context of Anterior Chamber


  1. The immunology of corneal graft rejection. Rocha, G., Deschênes, J., Rowsey, J.J. Crit. Rev. Immunol. (1998) [Pubmed]
  2. Effect of ibopamine on aqueous humor production in normotensive humans. McLaren, J.W., Herman, D.C., Brubaker, R.F., Nau, C.B., Wayman, L.L., Ciarniello, M.G., Rosignoli, M.T., Dionisio, P. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  3. Increased CD4+ expression and decreased IL-10 in the anterior chamber in idiopathic uveitis. Calder, V.L., Shaer, B., Muhaya, M., Mclauchlan, M., Pearson, R.V., Jolly, G., Towler, H.M., Lightman, S. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  4. Efficacy and safety of memantine treatment for reduction of changes associated with experimental glaucoma in monkey, I: Functional measures. Hare, W.A., WoldeMussie, E., Lai, R.K., Ton, H., Ruiz, G., Chun, T., Wheeler, L. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  5. Anterior chamber-associated immune deviation induced by soluble antigens. Mizuno, K., Clark, A.F., Streilein, J.W. Invest. Ophthalmol. Vis. Sci. (1989) [Pubmed]
  6. Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome. Semina, E.V., Reiter, R., Leysens, N.J., Alward, W.L., Small, K.W., Datson, N.A., Siegel-Bartelt, J., Bierke-Nelson, D., Bitoun, P., Zabel, B.U., Carey, J.C., Murray, J.C. Nat. Genet. (1996) [Pubmed]
  7. Fas ligand-induced apoptosis as a mechanism of immune privilege. Griffith, T.S., Brunner, T., Fletcher, S.M., Green, D.R., Ferguson, T.A. Science (1995) [Pubmed]
  8. Systemic immune unresponsiveness induced in adult mice by anterior chamber presentation of minor histocompatibility antigens. Streilein, J.W., Niederkorn, J.Y., Shadduck, J.A. J. Exp. Med. (1980) [Pubmed]
  9. Comparison of flubendazole and diethylcarbamazine in treatment of onchocerciasis. Dominguez-Vazquez, A., Taylor, H.R., Greene, B.M., Ruvalcaba-Macias, A.M., Rivas-Alcala, A.R., Murphy, R.P., Beltran-Hernandez, F. Lancet (1983) [Pubmed]
  10. A spectrum of FOXC1 mutations suggests gene dosage as a mechanism for developmental defects of the anterior chamber of the eye. Nishimura, D.Y., Searby, C.C., Alward, W.L., Walton, D., Craig, J.E., Mackey, D.A., Kawase, K., Kanis, A.B., Patil, S.R., Stone, E.M., Sheffield, V.C. Am. J. Hum. Genet. (2001) [Pubmed]
  11. The effects of intraocular injection of interleukin-13 on endotoxin-induced uveitis in rats. Lemaitre, C., Thillaye-Goldenberg, B., Naud, M.C., de Kozak, Y. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  12. Direct delivery of anticancer agents: experimental treatment of intraocular malignancy. Liu, H.S., Refojo, M.F., Perry, H.D., Albert, D.M. Invest. Ophthalmol. Vis. Sci. (1978) [Pubmed]
  13. Effect of chronically administered timolol on aqueous humor flow in patients with glaucoma. Brubaker, R.F., Nagataki, S., Bourne, W.M. Ophthalmology (1982) [Pubmed]
  14. Fluorophotometry and the blood-ocular barrier in experimental systemic hypertension. Dutton, J.J., Krupin, T., Waltman, S.R., Koloms, B.A., Becker, B. Arch. Ophthalmol. (1980) [Pubmed]
  15. Low doses of pilocarpine do not significantly increase outflow facility in the cynomolgus monkey. Kiland, J.A., Hubbard, W.C., Kaufman, P.L. Exp. Eye Res. (2000) [Pubmed]
  16. Augmentation of suppression in cyclophosphamide-treated rats bearing allogeneic skin implants in the anterior chamber of the eye. Grogan, J.B., Subba Rao, D.S., Henry, S.E. Invest. Ophthalmol. Vis. Sci. (1985) [Pubmed]
  17. Stimulation of cell division by argon and Nd:YAG laser trabeculoplasty in cynomolgus monkeys. Dueker, D.K., Norberg, M., Johnson, D.H., Tschumper, R.C., Feeney-Burns, L. Invest. Ophthalmol. Vis. Sci. (1990) [Pubmed]
  18. Heterotransplantation of retinoblastoma into the athymic "nude" mouse. Gallie, B.L., Albert, D.M., Wong, J.J., Buyukmihci, N., Pullafito, C.A. Invest. Ophthalmol. Vis. Sci. (1977) [Pubmed]
  19. In vivo gene transfer into murine corneal endothelial and trabecular meshwork cells. Budenz, D.L., Bennett, J., Alonso, L., Maguire, A. Invest. Ophthalmol. Vis. Sci. (1995) [Pubmed]
  20. Estrogen and progestin receptors appear in transplanted fetal hypothalamus-preoptic area independently of the steroid environment. Paden, C.M., Gerlach, J.L., McEwen, B.S. J. Neurosci. (1985) [Pubmed]
  21. Analysis of immunomodulatory activities of aqueous humor from eyes of mice with experimental autoimmune uveitis. Ohta, K., Wiggert, B., Yamagami, S., Taylor, A.W., Streilein, J.W. J. Immunol. (2000) [Pubmed]
  22. NK T cell-derived IL-10 is essential for the differentiation of antigen-specific T regulatory cells in systemic tolerance. Sonoda, K.H., Faunce, D.E., Taniguchi, M., Exley, M., Balk, S., Stein-Streilein, J. J. Immunol. (2001) [Pubmed]
  23. T cell immunity induced by allogeneic microglia in relation to neuronal retina transplantation. Ma, N., Streilein, J.W. J. Immunol. (1999) [Pubmed]
  24. APCs in the anterior uveal tract do not migrate to draining lymph nodes. Dullforce, P.A., Garman, K.L., Seitz, G.W., Fleischmann, R.J., Crespo, S.M., Planck, S.R., Parker, D.C., Rosenbaum, J.T. J. Immunol. (2004) [Pubmed]
  25. Light-induced damage to ocular lens cation pump: prevention by vitamin C. Varma, S.D., Kumar, S., Richards, R.D. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  26. Synapse formation in response to estrogen in the medial amygdala developing in the eye. Nishizuka, M., Arai, Y. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  27. Parasympathetic, sympathetic, and sensory interactions in the iris: nerve growth factor regulates cholinergic ciliary ganglion innervation in vivo. Kessler, J.A. J. Neurosci. (1985) [Pubmed]
  28. Retinal venous sheathing in optic neuritis. Its significance for the pathogenesis of multiple sclerosis. Lightman, S., McDonald, W.I., Bird, A.C., Francis, D.A., Hoskins, A., Batchelor, J.R., Halliday, A.M. Brain (1987) [Pubmed]
  29. A novel missense mutation in the sodium bicarbonate cotransporter (NBCe1/SLC4A4) causes proximal tubular acidosis and glaucoma through ion transport defects. Dinour, D., Chang, M.H., Satoh, J., Smith, B.L., Angle, N., Knecht, A., Serban, I., Holtzman, E.J., Romero, M.F. J. Biol. Chem. (2004) [Pubmed]
  30. Inhibition of angiogenesis by adenovirus-mediated sFlt-1 expression in a rat model of corneal neovascularization. Lai, C.M., Brankov, M., Zaknich, T., Lai, Y.K., Shen, W.Y., Constable, I.J., Kovesdi, I., Rakoczy, P.E. Hum. Gene Ther. (2001) [Pubmed]
  31. Placental Fas ligand expression is a mechanism for maternal immune tolerance to the fetus. Kauma, S.W., Huff, T.F., Hayes, N., Nilkaeo, A. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  32. Ocular anterior chamber dysgenesis in craniosynostosis syndromes with a fibroblast growth factor receptor 2 mutation. Okajima, K., Robinson, L.K., Hart, M.A., Abuelo, D.N., Cowan, L.S., Hasegawa, T., Maumenee, I.H., Jabs, E.W. Am. J. Med. Genet. (1999) [Pubmed]
  33. Reversal of abnormalities in ocular fluorophotometry in insulin-dependent diabetes after five to nine months of improved metabolic control. White, N.H., Waltman, S.R., Krupin, T., Santiago, J.V. Diabetes (1982) [Pubmed]
  34. Indomethacin and epinephrine effects on outflow facility and cyclic adenosine monophosphate formation in monkeys. Crawford, K.S., Gange, S.J., Gabelt, B.T., Heideman, W., Robinson, J.C., Hubbard, W.C., Kaufman, P.L. Invest. Ophthalmol. Vis. Sci. (1996) [Pubmed]
  35. A comparison of the effects of topical cyclosporine and topical steroid on rabbit corneal allograft rejection. Williams, K.A., Grutzmacher, R.D., Roussel, T.J., Coster, D.J. Transplantation (1985) [Pubmed]
  36. A scanning ocular spectrofluorophotometer. McLaren, J.W., Brubaker, R.F. Invest. Ophthalmol. Vis. Sci. (1988) [Pubmed]
  37. Biometric confirmation of the Hirschberg ratio in strabismic children. Hasebe, S., Ohtsuki, H., Kono, R., Nakahira, Y. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
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